{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:36:37Z","timestamp":1777934197546,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Radioimmunotherapy has emerged as a treatment modality for patients with CD20 positive B-cell non-Hodgkin\u2019s lymphoma (NHL). Prior to administration of a therapeutic dose, confirmation of uptake of the radiolabeled compound in tumor locations and calculation of an appropriate dose can be performed using a diagnostic dose and subsequent imaging. We report the case of a 69-year-old male with a relapsed mantle cell lymphoma scheduled for radioimmunotherapy, where diagnostic imaging with 131-I labeled rituximab revealed unexpected new insights with implications for treatment. Persistence of the mantle cell lymphoma in a lymph node in the left arm was demonstrated by an 18-F fluorodeoxyglucose scan. However, a scan after a diagnostic dose of 131-I labeled rituximab did not show any uptake of the tracer, even though subsequent cytological analysis unequivocally confirmed a CD20 positive B-cell population in the lesion. The administration of a therapeutic dose of 131-I labeled rituximab was therefore cancelled. We here discuss the mechanisms that may explain lack of targeting in a proven CD20-positive lymphoma and provide recommendations for further studies.<\/jats:p>","DOI":"10.1177\/1078155211428998","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T21:50:43Z","timestamp":1325886643000},"page":"417-420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of tumor uptake of 131-I labeled rituximab in a patient with a CD20 positive lymphoma lesion"],"prefix":"10.1177","volume":"18","author":[{"given":"L","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute\/Slotervaart Hospital, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADR","family":"Huitema","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute\/Slotervaart Hospital, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WV","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JH","family":"Beijnen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute\/Slotervaart Hospital, Amsterdam, The Netherlands; 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