{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:36:42Z","timestamp":1777934202083,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Pemetrexed is indicated for locally advanced or metastatic non-squamous non-small-cell lung cancer as an initial treatment in combination with cisplatin or after prior chemotherapy as a single agent. It is generally a well-tolerated drug. The most common adverse reactions (incidence \u226520%) with single-agent use are fatigue, nausea, and anorexia. Additional common side effects when used in combination with cisplatin include vomiting, neutropenia, leukopenia, anemia, stomatitis\/pharyngitis, thrombocytopenia, and constipation. Peripheral edema with associated erythema has rarely been described as an adverse effect. Herein, we report a patient with advanced non-small-cell lung cancer who experienced bilateral peripheral edema after pemetrexed administration. Discontinuation of pemetrexed and corticosteroids use completely resolved peripheral edema.<\/jats:p>","DOI":"10.1177\/1078155212438453","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T20:27:29Z","timestamp":1329942449000},"page":"93-94","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Pemetrexed-induced cellulitis: A rare toxicity in non-small cell lung cancer treatment"],"prefix":"10.1177","volume":"19","author":[{"given":"Stamatis","family":"Katsenos","sequence":"first","affiliation":[{"name":"Department of Pneumonology, Army General Hospital of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthoula","family":"Psara","sequence":"additional","affiliation":[{"name":"Department of Pneumonology, Army General Hospital of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chara","family":"Panagou","sequence":"additional","affiliation":[{"name":"Department of Pneumonology, Army General Hospital of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,22]]},"reference":[{"key":"bibr1-1078155212438453","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-6-363"},{"key":"bibr2-1078155212438453","unstructured":"European Medicines Agency: EPARs for authorized medicinal products for human use: Alimta. www.emea.europa.eu (accessed 1 May 2008)."},{"key":"bibr3-1078155212438453","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn118"},{"key":"bibr4-1078155212438453","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318207f788"},{"key":"bibr5-1078155212438453","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31822e722f"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155212438453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155212438453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155212438453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:14:33Z","timestamp":1777688073000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155212438453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,22]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/1078155212438453"],"URL":"https:\/\/doi.org\/10.1177\/1078155212438453","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,22]]}}}