{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:36:48Z","timestamp":1777934208455,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T00:00:00Z","timestamp":1357257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Romiplostim, a thrombopoietin mimetic, is FDA approved for the treatment of thrombocytopenia in patients with refractory immune thrombocytopenia. Given the success of thrombopoietin agonists in the treatment of immune thrombocytopenia, data in other clinical settings are emerging. In the bone marrow transplant setting, secondary failure of platelet recovery and persistent thrombocytopenia are associated with increased mortality. In this case, romiplostim was attempted in a chronic lymphocytic leukemia patient who underwent a matched, unrelated donor, non-myeloablative stem cell transplant. This patient experienced profound thrombocytopenia despite dose escalation. Anti-thrombopoietin or anti-romiplostim antibodies were not detected by specific assays. Furthermore, the patient remains in disease remission with full chimerism. This case demonstrates that heavily pre-treated patients with limited bone marrow reserve may not respond to thrombopoietin agonists.<\/jats:p>","DOI":"10.1177\/1078155212469640","type":"journal-article","created":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T23:08:43Z","timestamp":1357340923000},"page":"369-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Romiplostim resistance in secondary failure of platelet recovery"],"prefix":"10.1177","volume":"19","author":[{"given":"David L","family":"DeRemer","sequence":"first","affiliation":[{"name":"University of Georgia College of Pharmacy, Georgia Health Sciences University Cancer Center, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Katsanevas","sequence":"additional","affiliation":[{"name":"Georgia Health Sciences University Medical Center, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Bradley","sequence":"additional","affiliation":[{"name":"University of Georgia College of Pharmacy, Georgia Health Sciences University Cancer Center, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farrukh T","family":"Awan","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program, Division of Hematology\/Oncology, Department of Medicine, Georgia Health Sciences University, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,4]]},"reference":[{"key":"bibr1-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2001.v7.pm11302549"},{"key":"bibr2-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198603203141201"},{"key":"bibr3-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002625"},{"key":"bibr4-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60959-2"},{"key":"bibr5-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-274753"},{"key":"bibr6-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01832.x"},{"key":"bibr7-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.179"},{"key":"bibr8-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.298"},{"key":"bibr9-1078155212469640","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2003.05.001"},{"key":"bibr10-1078155212469640","unstructured":"Amgen Inc. 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