{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:36:55Z","timestamp":1777934215101,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:00:00Z","timestamp":1378252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The current standard for prevention of chemotherapy-induced nausea\/vomiting in autologous stem cell transplant only achieves 4\u201320% emetic control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess emetic responses to multiday palonosetron, aprepitant, and low-dose dexamethasone among patients with myeloma and lymphoma undergoing autologous hematopoietic stem cell transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Oral aprepitant 125\/80\/80\u2009mg was administered with intravenous dexamethasone 4\u2009mg and palonosetron 0.25\u2009mg on days \u22123, \u22122, \u22121 for multiple myeloma and days \u22127 through \u22123 for lymphoma. Palonosetron was repeated day +3 in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 20 patients were enrolled and 18 analyzed. None experienced emetic failure with complete control achieved in 78, 33, and 17% in the acute, delayed, and extended phases, respectively. Nausea occurred in 78% although not significant in 61%, with median Nausea Visual Score of 4.5. Quality of life correlated with emetic and nausea control. Eight patients developed grade 2\u20133 nonhematologic toxicities with only one event attributed to the study medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This triplet regimen was feasible with acceptable safety profile in the autologous hematopoietic stem cell transplant setting. Emetic control was best achieved in the acute phase. Lesser degree of emetic and nausea control in the delayed and extended phases impacted quality of life. Our results warrant further evaluation in a larger autologous hematopoietic stem cell transplant population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155213502103","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:45:29Z","timestamp":1378341929000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Combined use of multiday palonosetron with aprepitant and low-dose dexamethasone in prevention of nausea and emesis among patients with multiple myeloma and lymphoma undergoing autologous hematopoietic stem cell transplant: A pilot study"],"prefix":"10.1177","volume":"20","author":[{"given":"Delva","family":"Deauna-Limayo","sequence":"first","affiliation":[{"name":"Hematology\/Oncology, UC San Diego Nevada Cancer Institute, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar S","family":"Aljitawi","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhartha","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Abhyankar","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo A","family":"Wick","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P","family":"McGuirk","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,4]]},"reference":[{"key":"bibr1-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.1.103"},{"key":"bibr2-1078155213502103","first-page":"84","volume":"91","author":"Lopez-Jimenez J","year":"2006","journal-title":"Haematologica"},{"key":"bibr3-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702424"},{"key":"bibr4-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318172fa74"},{"key":"bibr5-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005275061"},{"key":"bibr6-1078155213502103","first-page":"9","volume":"18","author":"Hesketh PJ","year":"2004","journal-title":"Oncology"},{"key":"bibr7-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.0135.x"},{"key":"bibr8-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00066-3"},{"key":"bibr9-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X40481"},{"key":"bibr10-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq457"},{"key":"bibr11-1078155213502103","doi-asserted-by":"publisher","DOI":"10.1177\/1078155209105399"},{"key":"bibr12-1078155213502103","doi-asserted-by":"crossref","unstructured":"Jordan K, Jahn F, Jahn P, et\u00a0al. The NK-1 receptor antagonist aprepitant in high dose (HD) chemotherapy (HD melphalan and HD T-ICE: paclitaxel, ifosfamide, carboplatin, etoposide): Efficacy and safety of triple antiemetic combination.\n                      Bone Marrow Transplant\n                      . Epub ahead of print 13 September 2010. 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