{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:37:19Z","timestamp":1777934239475,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T00:00:00Z","timestamp":1420502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Sorafenib which is used in the treatment of renal, thyroid and hepatocellular cancers is a multi-targeted tyrosine kinase inhibitor. Though sorafenib is associated with some side effects, it is known that sorafenib is generally well tolerated compared to other tyrosine kinase inhibitors. In the present case, hepatocellular cancer was diagnosed seven months ago. The disease was in stage IIIB at the time of diagnosis. Sorafenib was initiated with a dose of 400\u2009mg twice daily because of disease progression after two cycles of doxorubicin. The reactions on the skin of the arms and the body of the patient occurred in the eighth week of treatment. Skin biopsy was performed and urticaria was diagnosed after pathologic examination. No other disorders or drugs which may cause urticaria were detected in the patient. Skin reactions disappeared one week after sorafenib discontinuation without any further intervention.<\/jats:p>","DOI":"10.1177\/1078155214565126","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T20:42:17Z","timestamp":1420663337000},"page":"350-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Sorafenib-induced severe urticaria in a patient with hepatocellular cancer"],"prefix":"10.1177","volume":"22","author":[{"given":"Fatma Yal\u00e7\u0131n","family":"Musri","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"K\u0131vrak Salim","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melek","family":"Karakurt Ery\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Tural","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"\u015eenol Co\u015fkun","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"key":"bibr1-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61613-9"},{"key":"bibr2-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"bibr3-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037563"},{"key":"bibr4-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08357.x"},{"key":"bibr5-1078155214565126","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.suponc.2010.10.003","volume":"8","author":"Balagula Y","year":"2010","journal-title":"J Support Oncol"},{"key":"bibr6-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09290.x"},{"key":"bibr7-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6723"},{"key":"bibr8-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-007-0145-8"},{"key":"bibr9-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1159\/000258880"},{"key":"bibr10-1078155214565126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04060.x"},{"key":"bibr11-1078155214565126","unstructured":"http:\/\/www.ehealthme.com\/ds\/nexavar (accessed 2014)."},{"key":"bibr12-1078155214565126","doi-asserted-by":"crossref","unstructured":"Wilgus TA, Matthies AM, Radek KA, et\u00a0al. 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