{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:37:21Z","timestamp":1777934241912,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Ipilimumab, monoclonal antibody against cytotoxic T-lymphocyte antigen-4 and, radiotherapy are commonly used to treat unresectable and metastatic melanoma. As a result of upregulation of immune system with ipilimumab, many immune-related adverse effects, such as dermatitis, colitis, hepatitis, and hypophysitis, have been previously reported in literature. Typically, these effects are treated with high-dose steroids and mostly heal up. Here, we report a case who was receiving radiotherapy due to metastatic malignant melanoma with atypical generalized rash, which was enlarged with concurrent ipilimumab treatment.<\/jats:p>","DOI":"10.1177\/1078155215572930","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T20:43:57Z","timestamp":1424292237000},"page":"533-536","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ipilimumab may increase the severity of cutenaous toxicity related to radiotherapy"],"prefix":"10.1177","volume":"22","author":[{"given":"Melek Karakurt","family":"Ery\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Akdeniz University 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