{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:37:22Z","timestamp":1777934242457,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Hairy cell leukemia patients are at increased risk for second malignancies, including both solid and lymphoid neoplasms. Along with other factors, multiple immune defects present in hairy cell leukemia likely contribute to subsequent carcinogenesis. We report herein a case of synchronous high-grade gastric and ampullary adenocarcinomas in a patient with a history of hairy cell leukemia treated eight years prior with pentostatin. We include a review of immune alterations induced by both hairy cell leukemia and its therapies, and link them with the occurrence of second cancers in these patients.<\/jats:p>","DOI":"10.1177\/1078155215574140","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T07:34:39Z","timestamp":1424936079000},"page":"543-547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Synchronous gastric and ampullary adenocarcinomas in a hairy cell leukemia patient treated with pentostatin eight years prior"],"prefix":"10.1177","volume":"22","author":[{"given":"Frank J","family":"Senatore","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin A","family":"Dasanu","sequence":"additional","affiliation":[{"name":"Lucy Curci Cancer Center, Eisenhower Medical Center\/University of Southern California, Rancho Mirage, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"bibr1-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903427951"},{"key":"bibr2-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12908"},{"key":"bibr3-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.9.1481"},{"key":"bibr4-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903405647"},{"key":"bibr5-1078155215574140","first-page":"92","volume":"8","author":"Burton J","year":"1994","journal-title":"Leukemia"},{"key":"bibr6-1078155215574140","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709059679"},{"key":"bibr7-1078155215574140","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009057632"},{"key":"bibr8-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.11.4224"},{"key":"bibr9-1078155215574140","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309148536"},{"key":"bibr10-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb01279.x"},{"key":"bibr11-1078155215574140","first-page":"340","volume":"66","author":"Netea MG","year":"2008","journal-title":"Neth J Med"},{"key":"bibr12-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1048.2001.03318.x"},{"key":"bibr13-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.2906.2906"},{"key":"bibr14-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1080\/10428199909169620"},{"key":"bibr15-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.5.848"},{"key":"bibr16-1078155215574140","first-page":"584","volume":"4","author":"Ho AD","year":"1990","journal-title":"Leukemia"},{"key":"bibr17-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.6.2257"},{"key":"bibr18-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4980"},{"key":"bibr19-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850915)56:6<1462::AID-CNCR2820560639>3.0.CO;2-6"},{"key":"bibr20-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181f7b30f"},{"key":"bibr21-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.1803"},{"key":"bibr22-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1160"},{"key":"bibr23-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.638"},{"key":"bibr24-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00732.x"},{"key":"bibr25-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk030"},{"key":"bibr26-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.2931.2931"},{"key":"bibr27-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921015)70:8<2087::AID-CNCR2820700813>3.0.CO;2-P"},{"key":"bibr28-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.6.1918"},{"key":"bibr29-1078155215574140","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-508754"},{"key":"bibr30-1078155215574140","doi-asserted-by":"crossref","unstructured":"Senatore FJ, Ynson ML and Dasanu CA. Adenocarcinoma of the ampulla of Vater: what treatment options are available?\n                      J Oncol Pharm Pract\n                      2014; ii: 1078155214538086. 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