{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:13:25Z","timestamp":1790230405067,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Appropriate use of oral chemotherapy is a challenge for patients and clinicians. The purpose of this study was to analyze cancer patients\u2019 use of oral chemotherapies and identify opportunities to improve adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed a 30-question survey to address frequency and reasons for reducing\/skipping doses; sources of information for oral chemotherapy use; perceived importance of food\u2013drug effects; and ease of understanding labeling directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-three patients taking oral chemotherapies with chronic myeloid leukemia, renal cell carcinoma, breast cancer, and colorectal cancer completed the survey. This was a well-educated population with 69% (n\u2009=\u200962) having completed some college; 51% (n\u2009=\u200947) female and 59% (n\u2009=\u200954) older than 50 years of age. Thirty percent of patients reported forgetting to take their oral chemotherapy at least \u201csometimes\u201d. Younger patients (&lt;50 vs. \u226550, p\u2009=\u20090.002), shorter treatment duration (&lt;6 vs. \u22656 months p\u2009=\u20090.03), or with chronic myeloid leukemia (vs. other diagnoses, p\u2009=\u20090.015) forget to take their oral chemotherapy at higher rates. Twenty-three percent (n\u2009=\u200921) indicated they intentionally skipped their oral chemotherapies and 38% (n\u2009=\u20098) of those did not inform their physicians. Forty-one percent (n\u2009=\u200928) taking drugs with significant food\u2013drug effects did not think about their last meal before taking their oral chemotherapy and 80% (n\u2009=\u200955) did not understand the potential interactions. Additionally, 39% (n\u2009=\u200936\/92) never looked at labeling and 15% (n\u2009=\u200914\/91) had difficulty understanding label directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There are three main barriers associated with appropriate use of oral chemotherapies: misunderstanding about the timing of drug with food; stopping drug without informing physicians; and difficulty understanding labeling directions. A multipronged approach is needed to optimize communication of directions for optimal oral chemotherapy use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155216679026","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T21:10:41Z","timestamp":1480367441000},"page":"98-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Patient perspectives on the barriers associated with medication adherence to oral chemotherapy"],"prefix":"10.1177","volume":"24","author":[{"given":"Benyam","family":"Muluneh","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center"},{"name":"Eshelman School of Pharmacy, University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Deal","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice D","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center"},{"name":"Eshelman School of Pharmacy, University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith D","family":"Keisler","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center"},{"name":"Eshelman School of Pharmacy, University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janell M","family":"Markey","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Neal","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Virginia Commonwealth University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bernard","sequence":"additional","affiliation":[{"name":"School of Medicine, University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Valgus","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center"},{"name":"Eshelman School of Pharmacy, University of North Carolina"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn G","family":"Dressler","sequence":"additional","affiliation":[{"name":"Eshelman School of Pharmacy, University of North Carolina"},{"name":"Fullerton Genetics Center, Mission Health Systems"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"bibr1-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1188\/03.CJON.S6.5-9"},{"key":"bibr2-1078155216679026","unstructured":"World Health Organization. Adherence to long-term therapies \u2013 evidence for action, http:\/\/apps.who.int\/iris\/bitstream\/10665\/42682\/1\/9241545992.pdf (2003)."},{"key":"bibr3-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604758"},{"key":"bibr4-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3087"},{"key":"bibr5-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.245"},{"key":"bibr6-1078155216679026","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20004"},{"key":"bibr7-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.9.652"},{"key":"bibr8-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.071"},{"key":"bibr9-1078155216679026","first-page":"588","volume":"36","author":"Chew LD","year":"2004","journal-title":"Fam Med"},{"key":"bibr10-1078155216679026","first-page":"603","volume":"20","author":"Hackshaw MD","year":"2014","journal-title":"J Manag Care Spec Pharm"},{"key":"bibr11-1078155216679026","first-page":"1006","volume":"20","author":"Trivedi D","year":"2014","journal-title":"J Manag Care Spec Pharm"},{"key":"bibr12-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2007.03.024"},{"key":"bibr13-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1331\/JAPhA.2009.07075"},{"key":"bibr14-1078155216679026","doi-asserted-by":"crossref","unstructured":"Erikson C, Salsberg E, Forte G, et al. Future supply and demand for oncologists: Challenges to assuring access to oncology services.\n                      J Oncol Pract\n                      2007; 3: 79\u201386.","DOI":"10.1200\/JOP.0723601"},{"key":"bibr15-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.000037"},{"key":"bibr16-1078155216679026","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp058328"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155216679026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155216679026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155216679026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:17:03Z","timestamp":1777688223000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155216679026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1177\/1078155216679026"],"URL":"https:\/\/doi.org\/10.1177\/1078155216679026","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]}}}