{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:19:41Z","timestamp":1789017581467,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Asparaginase is a chemotherapeutic agent that is commonly used in combination with other medications for the treatment of acute lymphoblastic leukemia. An adverse effect of asparaginase includes hepatotoxicity, which can lead to severe liver failure and death. Several reports have documented successful treatment of asparaginase-induced hepatotoxicity using levocarnitine (l-carnitine) and vitamin B complex. Herein, we report a patient with acute lymphoblastic leukemia that experienced acute liver injury following pegaspargase administration. Our patient was successfully treated with l-carnitine and vitamin B complex for 8 days and achieved recovery of hepatic function. Furthermore, we review the current literature and provide a recommendation on a regimen that can be used as an option for the treatment of asparaginase-induced hepatic injury.<\/jats:p>","DOI":"10.1177\/1078155217710714","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T07:54:34Z","timestamp":1495180474000},"page":"393-397","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Levocarnitine and vitamin B complex for the treatment of pegaspargase-induced hepatotoxicity: A case report and review of the literature"],"prefix":"10.1177","volume":"24","author":[{"given":"Alison","family":"Blackman","sequence":"first","affiliation":[{"name":"University of Connecticut School of Pharmacy, Storrs, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Boutin","sequence":"additional","affiliation":[{"name":"Hartford Hospital, Hartford, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Shimanovsky","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, University of Connecticut, Farmington, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Baker","sequence":"additional","affiliation":[{"name":"Hartford Hospital, Hartford, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Forcello","sequence":"additional","affiliation":[{"name":"Smilow Cancer Hospital at Yale New Haven, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"bibr1-1078155217710714","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.184769"},{"key":"bibr2-1078155217710714","doi-asserted-by":"publisher","DOI":"10.1159\/000442342"},{"key":"bibr3-1078155217710714","doi-asserted-by":"publisher","DOI":"10.1159\/000095827"},{"key":"bibr4-1078155217710714","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42647"},{"key":"bibr5-1078155217710714","doi-asserted-by":"publisher","DOI":"10.1159\/000353402"},{"key":"bibr6-1078155217710714","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.596963"},{"key":"bibr7-1078155217710714","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1101098"},{"key":"bibr8-1078155217710714","unstructured":"\u201cAsparaginase.\u201d LiverTox. US National Library of Medicine. https:\/\/livertox.nlm.nih.gov (accessed 11 April 2017)."},{"key":"bibr9-1078155217710714","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.845886"},{"key":"bibr10-1078155217710714","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2016.11929355"},{"key":"bibr11-1078155217710714","doi-asserted-by":"crossref","unstructured":"Piatkowska-Jakubas B, et\u00a0al. Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the polish adult leukemia group.\n                      Pol Arch Med Wewn\n                      . 2008: 664\u2013669.","DOI":"10.20452\/pamw.518"},{"key":"bibr12-1078155217710714","doi-asserted-by":"crossref","unstructured":"Aldoss I, et\u00a0al. High-grade pegylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles.\n                      Blood\n                      2013: 2671.","DOI":"10.1182\/blood.V122.21.2671.2671"},{"key":"bibr13-1078155217710714","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200012010-00027"},{"key":"bibr14-1078155217710714","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199909000-00013"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155217710714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155217710714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155217710714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:17:24Z","timestamp":1777688244000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155217710714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,19]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1177\/1078155217710714"],"URL":"https:\/\/doi.org\/10.1177\/1078155217710714","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,19]]}}}