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Here we present the case of a chronic myeloid leukemia patient with an inadequate response to imatinib due to concurrent phenytoin administration. Conspicuously low imatinib plasma trough levels were documented. Imatinib dose was increased from 400 to 800\u2009mg with good response. In conclusion, drug-to-drug interactions should be ruled out in cases of resistance to tyrosine kinase inhibitor treatment. Potent inducers of cytochrome P450 isoenzyme CYP3A4, as phenytoin, could induce inadequate responses due to increased imatinib clearance and low imatinib trough plasma levels. Thus, this interaction should be avoided. When this is not possible, dose escalation of imatinib and measurement of plasma levels, if available, is recommended.<\/jats:p>","DOI":"10.1177\/1078155217743565","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T02:35:27Z","timestamp":1512354927000},"page":"694-698","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Inadequate response to imatinib treatment in chronic myeloid leukemia due to a drug interaction with phenytoin"],"prefix":"10.1177","volume":"25","author":[{"given":"S","family":"Osorio","sequence":"first","affiliation":[{"name":"Hematology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, 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