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To our knowledge, there have been no published cases of clinically significant posaconazole-digoxin drug\u2013drug interactions. We report an interaction between posaconazole (300\u2009mg by mouth daily) and digoxin (0.25\u2009mg by mouth daily, Monday through Friday) resulting in atrial fibrillation with slow ventricular response and degenerating into polymorphic ventricular tachycardia.<\/jats:p>","DOI":"10.1177\/1078155218801055","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T08:12:41Z","timestamp":1538035961000},"page":"1758-1761","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Posaconazole\u2013digoxin drug\u2013drug interaction mediated by inhibition of P-glycoprotein"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-5527","authenticated-orcid":false,"given":"Abby C","family":"Shumaker","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Blessing Hospital, Quincy, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather M","family":"Bullard","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Churpek","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology, Department of Medicine, The University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall W","family":"Knoebel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"bibr1-1078155218801055","first-page":"807","volume":"120","author":"Wakasugi H","year":"1992","journal-title":"Ann Intern Med"},{"key":"bibr2-1078155218801055","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.3.400"},{"key":"bibr3-1078155218801055","doi-asserted-by":"publisher","DOI":"10.1177\/106002809703100410"},{"key":"bibr4-1078155218801055","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3543-3551.2004"},{"key":"bibr5-1078155218801055","unstructured":"Noxafil\u00ae [package insert]. 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