{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:21:12Z","timestamp":1785799272523,"version":"3.56.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To estimate the relative risk of pulmonary toxicity in patients exposed to a bleomycin-based chemotherapy including filgrastim compared to a similar chemotherapy without filgrastim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nested case\u2013control study of patients treated with BEP (bleomycin, etoposide and cisplatin) for germ cell cancer or with ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) for Hodgkin\u2019s lymphoma at the H\u00f4tel-Dieu de L\u00e9vis Hospital between 31 October 2000 and 30 June 2016. The relative risk was estimated by an adjusted odds ratio (aOR) using a propensity score-adjusted regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen cases of pulmonary toxicity, representing 14.7% of the 88 patients included in the study, were matched with 65 controls. A higher proportion of women (31.8%) than men (11.3%) developed pulmonary toxicity although the difference was not statistically significant ( P\u2009=\u20090.08). Within the cohort, two deaths related to lung toxicity were observed among cases where no filgrastim was used. The risk of pulmonary toxicity associated with the addition of filgrastim was not statistically significant (aOR\u2009=\u20092.48 95% CI\u2009=\u20090.50 to 12.19).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results add further evidence that the concomitant use of filgrastim might not increase the risk of pulmonary toxicity of bleomycin. It also suggests that female patients might be more likely to develop this adverse effect. A clinical trial would be needed to confirm this result.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155218804293","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T02:18:07Z","timestamp":1539569887000},"page":"1638-1644","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk of pulmonary toxicity of bleomycin and filgrastim"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6735-3052","authenticated-orcid":false,"given":"Magali","family":"Laprise-Lachance","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Centre Int\u00e9gr\u00e9 de Sant\u00e9 et de Services Sociaux de Chaudi\u00e8re-Appalaches, site H\u00f4tel-Dieu de L\u00e9vis, L\u00e9vis, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lemieux","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux de la Mauricie-et-du-Centre-du-Qu\u00e9bec, site Centre hospitalier affili\u00e9 universitaire r\u00e9gional de Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-9750","authenticated-orcid":false,"given":"Jean-Pierre","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 Laval, Quebec City, Quebec, Canada"},{"name":"Population Health and Optimal Health Practices Unit, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"bibr1-1078155218804293","unstructured":"Cancer Care Ontario. 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