{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:39:21Z","timestamp":1777934361348,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2019,12]]},"abstract":"\n Introduction<\/jats:title>\n A few years after the discovery and development of anti-infectives, this therapeutic feat gave way to bacterial resistance because of the overconsumption of antibiotics, most often with unjustified prescriptions. The objective was to evaluate the compliance of the prescription of antibiotherapy in the pediatric onco-hematology unit of Rabat Children's Hospital and to determine the drug interactions.<\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n This is a retrospective study of anti-infectives prescriptions in pediatric onco-hematology. All prescriptions containing an antibiotic or antimycotic were isolated at the end of each month for analysis according to the ANSM standard. The variables of compliance analyzed in the prescriptions were: form, indication, posology, duration of the treatment, drug interactions and number of antibiotics which were prescribed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The prescriptions containing at least one anti-infective were 195. All the prescriptions were in conformity with their indications; 111 (57%) of the cases were conform with respect to all criteria; 20 (12%) prescriptions were not conform in their form, 12 (6.6%) contained at least one over-dosed drug and 52 (26.7%) contained at least one under-dosed drug. A drug interaction was found in 15 (7.7%) of cases, of which 12 (6.2%) are precautions for use. A drug interaction is present in 1(6,7%) cases when a single antibiotic is prescribed against 3 (20%) cases when 4 antibiotics are prescribed. ( p\u2009=\u20090.007).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The number of non-compliances in our study was high. It would therefore be advisable to recommend the establishment of an information system to minimize the non-compliances and to ensure a training program for young doctors on international recommendations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1078155218816779","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T23:54:22Z","timestamp":1544054062000},"page":"1811-1816","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of anti-infectives prescriptions in a pediatric hemato-oncological center: A retrospective study"],"prefix":"10.1177","volume":"25","author":[{"given":"Boubacar BF","family":"Diop","sequence":"first","affiliation":[{"name":"Analytical chemistry laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amine","family":"Cheikh","sequence":"additional","affiliation":[{"name":"Pharmacy department, Abulcasis University of Health Sciences, Cheikh Zaid Hospital, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Attjioui","sequence":"additional","affiliation":[{"name":"Analytical chemistry laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed R","family":"Ajaja","sequence":"additional","affiliation":[{"name":"Pharmacy department, Abulcasis University of Health Sciences, Cheikh Zaid Hospital, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafid","family":"Mefetah","sequence":"additional","affiliation":[{"name":"Ibn Sina Hospital, Pediatrics Hospital, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Bouatia","sequence":"additional","affiliation":[{"name":"Analytical chemistry laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco"},{"name":"Ibn Sina Hospital, Pediatrics Hospital, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"bibr1-1078155218816779","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6460.1721"},{"key":"bibr2-1078155218816779","doi-asserted-by":"publisher","DOI":"10.3917\/rce.005.0030"},{"key":"bibr3-1078155218816779","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.4.459"},{"key":"bibr4-1078155218816779","doi-asserted-by":"publisher","DOI":"10.1016\/S0755-4982(04)98780-5"},{"key":"bibr5-1078155218816779","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708143370709"},{"key":"bibr6-1078155218816779","unstructured":"http:\/\/ansm.sante.fr\/Dossiers\/Antibiotiques\/Bien-utiliser-les-antibiotiques\/(offset)\/0, (accessed 25 April 2017)."},{"key":"bibr7-1078155218816779","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2010.09.012"},{"key":"bibr8-1078155218816779","unstructured":"Marie G. Etude de la prescription des antibiotiqus dans le CSR\u00e9f de Bandiagara. Th\u00e8se, Pharm. Bamako, 2010."},{"key":"bibr9-1078155218816779","unstructured":"Ouedraogo M. Contribution \u00e0 l'am\u00e9lioration de l'antibioth\u00e9rapie dans le District de Bamako: analyse de la consommation des antibiotiques dans les officines. Carrefour de Lafiabougou et les Hirondelles. Th\u00e8se, Pharm, Bamako, 1997-74p ; N\u00b025."},{"key":"bibr10-1078155218816779","unstructured":"Sissoko R. Antibioth\u00e9rapie dans le service de traumatologie de l'H\u00f4pital. Gabriel Tour\u00e9-Th\u00e8se, Pharm. Bamako, 2000, N\u00b040."},{"key":"bibr11-1078155218816779","unstructured":"Kiouba J. Use of antibiotics in hospitals. Thesis, Pharm. Bamako ; 2003- 72 p; N\u00b011."},{"key":"bibr12-1078155218816779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02158.x"},{"key":"bibr13-1078155218816779","unstructured":"www.drugs.com\/drug-interactions\/diflucan-with-omeprazole-1096-630-1750-0.html (accessed 28 April 2017)."},{"key":"bibr14-1078155218816779","first-page":"126","volume":"24","author":"Benziane H","year":"2011","journal-title":"Ann Burns Fire Disast"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155218816779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155218816779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155218816779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:20:38Z","timestamp":1777688438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155218816779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1177\/1078155218816779"],"URL":"https:\/\/doi.org\/10.1177\/1078155218816779","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]}}}