{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:39:31Z","timestamp":1777934371424,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was conducted with the aim of making the contribution to a decision for treatment and determination of the modalities in patients diagnosed with non-Hodgk\u0131n lymphoma which increasingly become widespread in the geriatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Ninety-one patients aged over 65 years diagnosed with lymphoma and treated in Bezmialem Vak\u0131f University Medical Faculty Hospital and Haseki Training and Research Hospital between 2008 and 2013 were retrospectively evaluated. Finally, 63 patients for whom data could be reached were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Examining the results, histological diagnoses of our patients were as follows: diffuse large B-cell lymphoma (50.8%), follicular lymphoma (23.8%), marginal zone lymphoma (12.7%), mantle cell lymphoma (4.8%), T-cell lymphoma (4.8%), lymphoplasmacytic lymphoma (1.6%) and small lymphocytic lymphoma (1.6%). Stages at the time of diagnosis were early stage by 33.3% and late stage by 66.7%. Of the patients, 36.5% had a low-intermediate and 63.5% a high-intermediate International Prognostic Index score. According to the Eastern Cooperative Oncology Group scoring, 34.9% of the patients have an Eastern Cooperative Oncology Group score of 2\u20134. Activities of daily living score of 33.3% patients was under 5. Looking at the responses to treatment, the complete response was found in 50.8%, partial response in 4.8%, stable disease in 1.6% and progressive disease in 9.5% of the patients. The mean follow-up duration of patients was found as 25.2 months and disease-free survival after remission as 20.2 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that we have achieved a complete remission in more than half of our patients (50.8%). Based on this, treatment should aim remission in elderly patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155219839460","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T09:19:30Z","timestamp":1553851170000},"page":"99-104","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment modalities of non-Hodgkin lymphoma patients over 65 years of age: A two-center experience"],"prefix":"10.1177","volume":"26","author":[{"given":"Guven","family":"Cetin","sequence":"first","affiliation":[{"name":"Department of Hematology, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Ece Dogan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bayrampa\u015fa Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-3561","authenticated-orcid":false,"given":"Nilay Sengul","family":"Samanci","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesut","family":"Ayer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Haseki Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yahyal\u0131 Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iskender","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kanuni Training and Research Hospital Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia","family":"Bag","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Turgut","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"bibr1-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-416-2_1"},{"key":"bibr2-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1080\/00313020500370192"},{"key":"bibr3-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388470"},{"key":"bibr4-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276766"},{"key":"bibr5-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-067769"},{"key":"bibr6-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70069-9"},{"key":"bibr7-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00103-7"},{"key":"bibr8-1078155219839460","first-page":"135","volume":"20","author":"Balducci L","year":"2006","journal-title":"Oncology (Williston Park)"},{"key":"bibr9-1078155219839460","first-page":"206","volume":"62","author":"Oguchi M","year":"2002","journal-title":"Nippon Igaku Hoshasen Gakkai Zasshi"},{"key":"bibr10-1078155219839460","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.50.1.7"},{"key":"bibr11-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971215)80:12<2311::AID-CNCR13>3.0.CO;2-X"},{"key":"bibr12-1078155219839460","doi-asserted-by":"crossref","unstructured":"Wu XC, Andrews P, Chen VW and Groves FD. Incidence of extranodal non-Hodgkin lymphomas among whites, blacks, and Asians\/PacificIslanders in the United States: anatomic site and histology differences.\n                      Cancer Epidemiol\n                      2009; 33(5): 337\u201346.","DOI":"10.1016\/j.canep.2009.09.006"},{"key":"bibr13-1078155219839460","first-page":"135","volume":"20","author":"Balducci L","year":"2006","journal-title":"Oncology (Williston Park)"},{"key":"bibr14-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08934.x"},{"key":"bibr15-1078155219839460","first-page":"287","volume":"49","author":"Harboun M","year":"2001","journal-title":"Rev Epidemiol Sante Publique"},{"key":"bibr16-1078155219839460","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/10.suppl_6.S19"},{"key":"bibr17-1078155219839460","doi-asserted-by":"publisher","DOI":"10.3109\/02841869609098498"},{"key":"bibr18-1078155219839460","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009054885"},{"key":"bibr19-1078155219839460","unstructured":"Balducci L and Extermann M. 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