{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:39:44Z","timestamp":1777934384053,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Thymic carcinoma is a rare entity and can be distinguished from benign thymomas by their aggressive nature and poor prognosis. The National Comprehensive Cancer Network guidelines recommend resection followed by adjuvant platinum-based chemotherapy for resectable tumors. However, the outcomes for metastatic or relapsed thymic carcinomas are poor with no regimen showing a consistent benefit. Moreover, the relative rarity of these tumors makes clinical trials difficult. Molecular analysis of thymomas shows a high incidence of genetic mutations and targeted therapy holds promise. We will briefly outline and review the current role of targeted therapy in thymic cancer.<\/jats:p>","DOI":"10.1177\/1078155219852758","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T04:35:29Z","timestamp":1559622929000},"page":"1712-1718","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of targeted therapy in thymic carcinoma"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-5219","authenticated-orcid":false,"given":"Mridula","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Hematology Oncology, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apar K","family":"Ganti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA"},{"name":"Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"bibr1-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70273-9"},{"key":"bibr2-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-016-0194-4"},{"key":"bibr3-1078155219852758","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.01.79"},{"key":"bibr4-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.0487"},{"key":"bibr5-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318276241c"},{"key":"bibr6-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R"},{"key":"bibr7-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.11.004"},{"key":"bibr8-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.01.012"},{"key":"bibr9-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.06.007"},{"key":"bibr10-1078155219852758","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-009-0083-7"},{"key":"bibr11-1078155219852758","unstructured":"Ettinger DS, Wood DE and Aisner DL. NCCN clinical practice guidelines in oncology (NCCN guidelines\u00ae) thymomas and thymic Carcinomas.\n                      National comprehensive cancer network\n                      . https:\/\/www. nccn. org\/professionals\/physician_gls\/pdf\/thymic. pdf. 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