{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:07:42Z","timestamp":1790701662544,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Contamination of hospitals\u2019 surfaces with antineoplastic drugs is documented despite safe handling practices. The exterior of commercial containers is often contaminated during the manufacturing process and can cross-contaminate hospitals\u2019 surfaces. The aim was to investigate the contamination of the exterior of antineoplastic drug vials available in Canada in 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional study. All available antineoplastic drugs vials from a single wholesaler were targeted. Containers were sampled upon their receipt by the pharmacy staff, before they were cleaned. One wipe was used to sample the external surface of five vials from a single batch from the same manufacturer. Nine antineoplastic drugs were quantified by ultra-performance liquid chromatography\u2013tandem mass spectrometer: cyclophosphamide, docetaxel, 5-fluorouracil, gemcitabine, ifosfamide, irinotecan, methotrexate, paclitaxel, vinorelbine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-one samplings were done (105 containers from nine different manufacturers): cyclophosphamide\u2009=\u20092, docetaxel\u2009=\u20091, gemcitabine\u2009=\u20092, 5-fluorouracil\u2009=\u20092, ifosfamide\u2009=\u20092, irinotecan\u2009=\u20093, methotrexate\u2009=\u20096, paclitaxel\u2009=\u20092, vinorelbine\u2009=\u20091. One of these samplings was done on blister packaging, the remainder were done on glass vials. A total of 15\/21 samples (71%) were positive to at least one drug (docetaxel, 5-fluorouracil, ifosfamide, and vinorelbine). A maximum of 272\u2009ng\/vial was quantified (gemcitabine). Cross contamination with other antineoplastic drugs was detected on 16\/21 (76%) samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The majority of samples were positive to at least one antineoplastic drug, confirming that the exterior of antineoplastic drugs containers is still an important source of contamination. Manufacturers should reduce this contamination. Vials should be washed upon receipt, before they are stored in pharmacy. Gloves must be worn at all times to avoid occupational exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155219868525","type":"journal-article","created":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T07:57:15Z","timestamp":1566719835000},"page":"423-427","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["External contamination of antineoplastic drug containers from a Canadian wholesaler"],"prefix":"10.1177","volume":"26","author":[{"given":"D","family":"Hilliquin","sequence":"first","affiliation":[{"name":"Unit\u00e9 de recherche en pratique pharmaceutique, D\u00e9partement de pharmacie, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6623-4967","authenticated-orcid":false,"given":"JF","family":"Bussi\u00e8res","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche en pratique pharmaceutique, D\u00e9partement de pharmacie, CHU Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"key":"bibr1-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1177\/1078155218773862"},{"key":"bibr2-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.05.002"},{"key":"bibr3-1078155219868525","first-page":"761","volume":"58","author":"Hon CY","year":"2014","journal-title":"Ann Occup Hyg"},{"key":"bibr4-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1177\/1078155212459667"},{"key":"bibr5-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2018-001705"},{"key":"bibr6-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1007\/BF00381477"},{"key":"bibr7-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1177\/1078155213482683"},{"key":"bibr8-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.5.475"},{"key":"bibr9-1078155219868525","first-page":"765","volume":"52","author":"Touzin K","year":"2008","journal-title":"Ann Occupat Hygiene"},{"key":"bibr10-1078155219868525","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080621"},{"key":"bibr11-1078155219868525","first-page":"555","volume":"46","author":"Nygren O","year":"2002","journal-title":"Ann Occupat Hygiene"},{"key":"bibr12-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1191\/1078155203jp102oa"},{"key":"bibr13-1078155219868525","first-page":"629","volume":"49","author":"Hedmer M","year":"2005","journal-title":"Ann Occupat Hygiene"},{"key":"bibr14-1078155219868525","first-page":"55","volume":"144","author":"Funck S","year":"2004","journal-title":"Deutsche Apotheker Zeitung"},{"key":"bibr15-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1310\/hpj4904-355"},{"key":"bibr16-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-012-0742-z"},{"key":"bibr17-1078155219868525","doi-asserted-by":"publisher","DOI":"10.1177\/1078155210374673"},{"key":"bibr18-1078155219868525","unstructured":"Association paritaire pour la Sant\u00e9 et la S\u00e9curit\u00e9 du Travail du Secteur Affaires Sociales. Prevention guide, safe handling of hazardous drugs, http:\/\/www.asstsas.qc.ca\/sites\/default\/files\/publications\/documents\/Guides_Broch_Depl\/GP65A_hazardous_drugs.pdf (2008, accessed 15 July 2019)."}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155219868525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155219868525","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155219868525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:21:46Z","timestamp":1777688506000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155219868525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1177\/1078155219868525"],"URL":"https:\/\/doi.org\/10.1177\/1078155219868525","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,25]]}}}