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Most commonly encountered in mantle cell lymphoma, the extent to which RIAT occurs in splenic marginal zone lymphoma is unknown. In this report, we describe a case of RIAT in a patient with splenic marginal zone lymphoma. Rituximab was safely rechallenged with increased premedications and slowed infusion rate. While the exact mechanism of this phenomenon has yet to be elucidated, diligent monitoring of platelet counts following rituximab infusion can be considered in high-risk patients to avoid potential adverse events. Split dose rituximab for high-risk patients may provide an alternative approach to improve patient safety.<\/jats:p>","DOI":"10.1177\/1078155219890023","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T02:13:55Z","timestamp":1574734435000},"page":"1248-1253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful rechallenge of rituximab following severe rituximab-induced acute thrombocytopenia in a patient with splenic marginal zone lymphoma"],"prefix":"10.1177","volume":"26","author":[{"given":"Adam C","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, Barnes-Jewish Hospital, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5906-4733","authenticated-orcid":false,"given":"Victoria R","family":"Nachar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services and Clinical Sciences, Michigan Medicine, University of Michigan College of Pharmacy, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"bibr1-1078155219890023","volume-title":"RITUXAN\u00ae (rituximab) [package insert]","author":"Genentech, Inc"},{"key":"bibr2-1078155219890023","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0612-x"},{"key":"bibr3-1078155219890023","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21931"},{"key":"bibr4-1078155219890023","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.07.004"},{"key":"bibr5-1078155219890023","unstructured":"National Comprehensive Cancer Network. 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