{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:41:27Z","timestamp":1779237687632,"version":"3.51.4"},"reference-count":72,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The methylenetetrahydrofolate reductase gene C677T polymorphism is closely related to the acute lymphoblastic leukemia. Several case\u2013control studies have investigated this association; however, no conclusions could be drawn. A comprehensive updated meta-analysis is established to explain these contradictions and clarify the overall impact of this variant on the susceptibility to acute lymphoblastic leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic searches were conducted to select published studies prior to June 2018. Pooled odds ratios and stratification analysis were performed under different genetic comparison models, age, and ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Totally, 66 case\u2013control studies including 9619 acute lymphoblastic leukemia cases and 17,396 controls were selected. Our analyses showed that methylenetetrahydrofolate reductase C677T polymorphism was protective mainly in Asian and European countries, under all genetic models and regardless of age, but leukemogenic in mixed population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thus, C677T polymorphism may be a promising acute lymphoblastic leukemia biomarker, but they should be interpreted with caution considering other factors such as folic acid intake, gene\u2013gene and gene\u2013environment interactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155219900914","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:56:07Z","timestamp":1582073767000},"page":"1598-1610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-8785","authenticated-orcid":false,"given":"Rim","family":"Frikha","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Sfax, Sfax-Tunisia"},{"name":"Department of Medical Genetics, Hedi Chaker University Teaching Hospital, Sfax-Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"bibr1-1078155219900914","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12810"},{"key":"bibr2-1078155219900914","first-page":"1069","volume":"14","author":"Chen BA","year":"2006","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"bibr3-1078155219900914","doi-asserted-by":"crossref","unstructured":"Barbosa CG, Souza CL, Moura Neto JPd, et al. 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