{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:04:36Z","timestamp":1782831876234,"version":"3.54.5"},"reference-count":13,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors are becoming increasingly important in oncology. Immune-related adverse events, including autoimmune hypophysitis, have been reported before.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We present a case series of three males and one female, suffering from either malignant melanoma or renal cell carcinoma, who developed hypophysitis under Nivolumab and\/or Ipilimumab. A wide range of clinical manifestations from asymptomatic hypophysitis, headache, general weakness, loss of appetite, visual field impairment, and confusion to acute life-threatening Addison crisis was observed. Management and outcome: All patients received corticosteroids. Immune checkpoint inhibitors were discontinued in three cases until resolution of symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The objective of our report is to raise the awareness of physicians, regarding this rare clinical entity, which may become life-threatening, if not promptly recognized and properly treated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220910202","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T02:07:29Z","timestamp":1584065249000},"page":"1774-1779","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Autoimmune hypophysitis secondary to therapy with immune checkpoint inhibitors: Four cases describing the clinical heterogeneity of central endocrine dysfunction"],"prefix":"10.1177","volume":"26","author":[{"given":"Amelie","family":"Hartmann","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Endocrinology, Diabetology and General Medicine, Klinikum Kassel, Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-6759","authenticated-orcid":false,"given":"Maria","family":"Paparoupa","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern G","family":"Volkmer","sequence":"additional","affiliation":[{"name":"Department of Urology, Klinikum Kassel, Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rompel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Klinikum Kassel, Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wittig","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Endocrinology, Diabetology and General Medicine, Klinikum Kassel, Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schuppert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Endocrinology, Diabetology and General Medicine, Klinikum Kassel, Kassel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"bibr1-1078155220910202","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0509"},{"key":"bibr2-1078155220910202","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pky021"},{"key":"bibr3-1078155220910202","doi-asserted-by":"publisher","DOI":"10.1177\/1078155217727142"},{"key":"bibr4-1078155220910202","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1268-18"},{"key":"bibr5-1078155220910202","first-page":"341","volume":"16","author":"Ntali G","year":"2017","journal-title":"Hormones 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