{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:40:40Z","timestamp":1777934440408,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Nelarabine is a purine analogue approved for the treatment of patients with T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukaemia (T-ALL) that have relapsed or are refractory to two previous chemotherapy regimens. Adverse reactions to nelarabine include neurological toxicity, the pathophysiological mechanisms of which are unknown, although the administration of intrathecal therapy at therapeutic doses given concomitantly with high-dose systemic chemotherapy that crosses the blood\u2013brain barrier may potentiate neurotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report a case of a 29-year-old woman with a diagnosis of relapsed T-ALL who developed severe myelopathy and polyneuropathy of toxic origin that led to paraplegia, upper-limb paresis, and dysautonomia after the first cycle of nelarabine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>Rehabilitation and pharmacological treatments were initiated early, but no evidence of a significant clinical change was obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Neurotoxicity is a dose-dependent side effect of nelarabine. It is therefore important to consider previously administered neurotoxic drugs before using nelarabine and to monitor patients closely so as to be able to act promptly in case of toxicity. In accordance with the data obtained and based on the Naranjo algorithm, the adverse reaction could be considered possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220929747","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T01:17:17Z","timestamp":1591751837000},"page":"244-249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Nelarabine-associated myelopathy in a patient with acute lymphoblastic leukaemia: Case report"],"prefix":"10.1177","volume":"27","author":[{"given":"Neus","family":"Amer-Salas","sequence":"first","affiliation":[{"name":"Department of Haematology, Son Ll\u00e0tzer Hospital, Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-607X","authenticated-orcid":false,"given":"Gonzalo","family":"Gonz\u00e1lez-Morcillo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Son Ll\u00e0tzer Hospital, Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Rodr\u00edguez-Camacho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Son Ll\u00e0tzer Hospital, Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Cladera-Serra","sequence":"additional","affiliation":[{"name":"Department of Haematology, Son Ll\u00e0tzer Hospital, Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"bibr1-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0317"},{"key":"bibr2-1078155220929747","unstructured":"Summary of Product Characteristics\/package leaflet Product information: ARRANON\u00ae intravenous injection, nelarabine intravenous injection. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2018."},{"key":"bibr3-1078155220929747","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1200\/JCO.2013.52.2425","volume":"32","author":"Ribera JM","year":"2014","journal-title":"J Clin Oncol"},{"key":"bibr4-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1397661"},{"key":"bibr5-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13178"},{"key":"bibr6-1078155220929747","doi-asserted-by":"crossref","unstructured":"Biller J, Ferro JM. Neurologic aspects of systemic disease, Part III. Preface.\n                      Handb Clin Neurol\n                      . 2014; 121: ix.","DOI":"10.1016\/B978-0-7020-4088-7.09991-0"},{"key":"bibr7-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21719"},{"key":"bibr8-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12173"},{"key":"bibr9-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2016.11.005"},{"key":"bibr10-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23502"},{"key":"bibr11-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.04.010"},{"key":"bibr12-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1177\/1078155214528018"},{"key":"bibr13-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.199"},{"key":"bibr14-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23550"},{"key":"bibr15-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.4728"},{"key":"bibr16-1078155220929747","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2015.025"},{"key":"bibr17-1078155220929747","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220929747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155220929747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220929747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:23:08Z","timestamp":1777688588000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155220929747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/1078155220929747"],"URL":"https:\/\/doi.org\/10.1177\/1078155220929747","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]}}}