{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:41:35Z","timestamp":1777934495793,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The use of bisphosphonates is increasing, for treatment of hypercalcemia and pain in cancer, and post-menopausal osteoporosis and also to decrease the risk of skeletal morbidity in multiple myeloma and metastatic breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A single dose of zoledronic acid was administered for hypercalcemia in a 54-year-old woman breast cancer patient with extensive bone metastasis. After the first dose, the patient developed symptomatic hypocalcemia.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Management and outcome:<\/jats:bold>\n                      Simultaneous hypocalcemia, hypophosphatemia, and vitamin D deficiency were detected in the patient. In the symptomatic process, intravenous, then oral replacement was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>There is a need for taking precautionary measures such as vitamin D, serum phosphorus and, calcium monitoring and supplementation to prevent life-threatening complications, such as symptomatic hypocalcemia, especially in populations with vitamin D deficiency like ours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220940411","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T02:40:52Z","timestamp":1594694452000},"page":"494-497","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Symptomatic hypocalcemia following a single dose of zoledronic acid in a patient with bone metastases secondary to breast cancer"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-1588","authenticated-orcid":false,"given":"Hasan","family":"S\u00f6zel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Akdeniz University Medical School, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-3299","authenticated-orcid":false,"given":"Fatih","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Antalya Atat\u00fcrk State Hospital, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"w13979","DOI":"10.4414\/smw.2014.13979","article-title":"Bisphosphonate induced hypocalcaemia \u2013 report of six cases and review of the literature.","volume":"144","author":"Kreutle V","year":"2014","unstructured":"Kreutle V, Blum C, Meier C, et\u00a0al. Bisphosphonate induced hypocalcaemia \u2013 report of six cases and review of the literature. Swiss Med Wkly 2014; 144: w13979.","journal-title":"Swiss Med Wkly"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(03)80327-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363040-00009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj105"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200304103481521"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.9.1557"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(01)90261-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574886311666160426141647"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.1.48"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06797.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.99.013"},{"key":"e_1_3_3_14_2","first-page":"83","article-title":"Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases","volume":"98","author":"Patel K","year":"2005","unstructured":"Patel K, Brahmbhatt V and, Ramu V. Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases. Tenn Med 2005; 98: 83\u201385.","journal-title":"Tenn Med"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.116"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.19.1458"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi162"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220940411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155220940411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220940411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:23:20Z","timestamp":1777688600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155220940411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1177\/1078155220940411"],"URL":"https:\/\/doi.org\/10.1177\/1078155220940411","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]}}}