{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:40:45Z","timestamp":1777934445286,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The fungal infection has become severe morbidity amongst patients with malignancy. Voriconazole, a new generation of triazole, has shown excellent results in treating invasive fungal infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>Herein, we report two cases of posterior reversible encephalopathy syndrome (PRES), which induced after voriconazole exposure.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Management and outcome:<\/jats:bold>\n                      Magnetic resonance imaging, and the serum level of voriconazole were investigated in both patients to assess toxicity. The role of methotrexate, as one of the possible causes of PRES, is weakened significantly through precise assessing diffusion-weighted images on  magnetic resonance imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These unique cases emphasize that voriconazole can induce PRES even at therapeutic levels. Therefore, in the case of neurotoxicity, PRES must be considered, and voriconazole should discontinue. The prognosis seemed promising when voriconazole stopped immediately after clinical suspicion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220941590","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T01:17:03Z","timestamp":1595294223000},"page":"498-504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Potential voriconazole associated posterior reversible leukoencephalopathy in children with malignancies: Report of two cases"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-2853","authenticated-orcid":false,"given":"Ali","family":"Amanati","sequence":"first","affiliation":[{"name":"Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrzad","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob Van","family":"Manen","sequence":"additional","affiliation":[{"name":"Oracle Health Sciences, Kattendijke, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Ali","family":"Faghihi","sequence":"additional","affiliation":[{"name":"Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL, USA"},{"name":"Persian BayanGene Research and Training Center, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Yavarian","sequence":"additional","affiliation":[{"name":"Persian BayanGene Research and Training Center, Shiraz, Iran"},{"name":"Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omidreza","family":"Zekavat","sequence":"additional","affiliation":[{"name":"Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Badiee","sequence":"additional","affiliation":[{"name":"Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazafarin Hatami","family":"Mazinani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haleh","family":"Bozorgi","sequence":"additional","affiliation":[{"name":"Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2649-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12584"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw099"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/524669"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/424662"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1971400915609338"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00111-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3810\/hp.2012.02.961"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00034"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omx011"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2018.1478563"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3283129746"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3196-2"},{"key":"e_1_3_3_16_2","first-page":"2832","volume-title":"Kucers' the use of antibiotics seventh edition: a clinical review of antibacterial, antifungal and antiviral drugs","author":"Michael Neely DN.","year":"2018","unstructured":"Michael Neely DN. Voriconazole. 6. Adverse reactions and toxicity. In: M Lindsay Grayson, et\u00a0al. (eds) Kucers' the use of antibiotics seventh edition: a clinical review of antibacterial, antifungal and antiviral drugs. Boca Raton, FL: CRC Press, 2018, p.2832."},{"key":"e_1_3_3_17_2","first-page":"2827","volume-title":"Kucers' the use of antibiotics seventh edition: a clinical review of antibacterial, antifungal and antiviral drugs","author":"Lindsay Grayson M","year":"2018","unstructured":"Lindsay Grayson M, et\u00a0al. Those requiring altered dosages (4d), patients with impaired hepatic function. In: DN Michael Neely (ed.) 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