{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:45:47Z","timestamp":1780717547990,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors. The common adverse drug reaction associated with 5-fluorouracil are myelosuppression, mucositis, diarrhea, and hand-foot syndrome. Neurological side effects such as headache, dizziness, convulsion, encephalopathy, and acute cerebellar syndrome are rare in nature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a case of 5-fluorouracil induced cerebrovascular accident (CVA) in a patient with no risk factors for CVA before chemotherapy. A 37\u2009years old female patient diagnosed with carcinoma rectum underwent six cycles of chemotherapy with 5- fluorouracil- calcium leucovorin- irinotecan (FOLFIRI regimen). After completing the last cycle, she developed headache, vomiting, and facial deviation along with high blood pressure (260\/160\u2009mmHg). MRI brain was done, and it revealed acute non-hemorrhagic lacunar infarct in the left half of pons. 5-fluorouracil induced CVA was suspected and was managed with dual antiplatelet, statin, and antihypertensives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The clinicians and clinical pharmacists must be aware about the potential of 5-FU to induce rare side effects such as CVA even in low risk patients in order to avoid permanent harm to the patient<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220954900","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T14:01:44Z","timestamp":1599660104000},"page":"1016-1019","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Case report on 5-fluorouracil induced cerebrovascular accident"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-8280","authenticated-orcid":false,"given":"Kavya","family":"Karthikeyan","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, St. Joseph's College of Pharmacy, Cherthala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy M","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, St. Joseph's College of Pharmacy, Cherthala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintu","family":"Shaji","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, St. Joseph's College of Pharmacy, Cherthala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin M","family":"Ashok","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lourdes Hospital, Kochi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CS","family":"Madhu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lourdes Hospital, Kochi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"bibr1-1078155220954900","unstructured":"Chu E and DeVita Jr VT.\n                      Physician\u2019s Cancer Chemotherapy Drug Manuel 2015\n                      . 15th ed. Jones & Bartlett Learning, 2014, p. 210 & 213."},{"key":"bibr2-1078155220954900","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2010.511610"},{"key":"bibr3-1078155220954900","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115686"},{"key":"bibr4-1078155220954900","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2011.129"},{"key":"bibr5-1078155220954900","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07882-8","volume":"10","author":"Zaorsky NG","year":"2019","journal-title":"Nat Commun"},{"key":"bibr6-1078155220954900","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.2.53"},{"key":"bibr7-1078155220954900","first-page":"779","volume":"54","author":"Dardiotis E","year":"2019","journal-title":"Int J Oncol"},{"key":"bibr8-1078155220954900","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0985-0"},{"key":"bibr9-1078155220954900","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2020.04.001"},{"key":"bibr10-1078155220954900","doi-asserted-by":"publisher","DOI":"10.1188\/14.CJON.581-585"},{"key":"bibr11-1078155220954900","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.152"},{"key":"bibr12-1078155220954900","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2017.07.022"},{"key":"bibr13-1078155220954900","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.154014"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220954900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155220954900","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220954900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:23:42Z","timestamp":1777688622000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155220954900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1177\/1078155220954900"],"URL":"https:\/\/doi.org\/10.1177\/1078155220954900","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]}}}