{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:41:13Z","timestamp":1777934473894,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hepatitis B virus (HBV) infection remains a global public health threat, with approximately 257 million people suffering from chronic HBV infection worldwide in 2015. HBV reactivation is a known complication of immunosuppressive therapy in people suffering with chronic HBV. Medications commonly associated with HBV reactivation include B-cell depleting agents and anthracycline derivatives. There have been very few documented cases of chemoradiation inducing HBV reactivation among scientific literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 44-year-old woman with chronic HBV infection and [FIGO] stage IIIB cervical cancer developed marked transaminitis and increased HBV viral load after receiving treatment with three doses of cisplatin and one dose of carboplatin with concurrent radiation for cervical cancer. Management and outcome: The patient was admitted for acute liver failure and quickly developed encephalopathy, with treatment complicated by coagulopathy, hypoglycemia, and metabolic acidosis. The patient remained unresponsive to maximal therapeutic efforts and was mechanically ventilated for airway protection. She subsequently died after experiencing ventricular tachycardia followed by asystole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>There are currently no standardized guidelines for the screening of HBV infection or prophylaxis treatment algorithm for patients undergoing chemoradiation. When initiating treatment with immunosuppressive therapy, it is important to screen all patients for chronic HBV infection and to work with an interdisciplinary team of oncologists, hepatologists, and pharmacists to initiate prophylactic antiviral therapy and closely monitor to minimize the risk of HBV reactivation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220964256","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T01:40:20Z","timestamp":1602726020000},"page":"1296-1301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Fatal hepatitis B reactivation in a patient receiving chemoradiation for cervical cancer"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-8011","authenticated-orcid":false,"given":"Colin","family":"Dimond","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Boston Medical Center, Boston, MA, USA"},{"name":"Department of Pharmacy Practice, University of the Pacific, Stockton, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Negroiu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0971-7265","authenticated-orcid":false,"given":"David","family":"M. Hughes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"bibr1-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"bibr2-1078155220964256","unstructured":"World Health Organization. Hepatitis B fact sheet, www.who.int\/mediacentre\/factsheets\/fs204\/en\/ (accessed 1 October 2020)."},{"key":"bibr3-1078155220964256","first-page":"370","volume":"10","author":"Kawsar HI","year":"2012","journal-title":"Clin Adv Hematol Oncol"},{"key":"bibr4-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.038"},{"key":"bibr5-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2931402"},{"key":"bibr6-1078155220964256","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.19034"},{"key":"bibr7-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyz046"},{"key":"bibr8-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"bibr9-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr10-1078155220964256","unstructured":"National Comprehensive Cancer Network. Prevention and treatment of cancer-related infections (version 2), http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/infections.pdf (2020, accessed 1 October 2020)."},{"key":"bibr11-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.3745"},{"key":"bibr12-1078155220964256","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2016.09.014"},{"key":"bibr13-1078155220964256","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1121"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220964256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155220964256","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220964256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:23:57Z","timestamp":1777688637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155220964256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/1078155220964256"],"URL":"https:\/\/doi.org\/10.1177\/1078155220964256","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,14]]}}}