{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:41:47Z","timestamp":1777934507016,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Netupitant\/palonestron (NEPA, Akynzeo\u2122) is a fixed combination of netupitant 300\u2009mg and palonosetron 0.5\u2009mg that is indicated for the prevention of chemotherapy-induced nausea and vomiting (CINV). NEPA is supplied as a hard gelatin capsule and indicated to be administered whole with or without food. The efficacy of NEPA was maintained when administered as an oral dose of netupitant given concomitantly (in separate formulations after removal from the hard gelatin capsule) with a single oral dose of palonosetron. At our institution, two patients experienced difficulty swallowing the capsule leading to opening the capsule and individual administration of the medications. We observed that the efficacy was maintained when the opened NEPA capsule was administered as individual medications. We report the details of these two patient cases.<\/jats:p>","DOI":"10.1177\/1078155220965671","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:56:57Z","timestamp":1603673817000},"page":"1284-1286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Capsule-related dysphagia and the use of netupitant\/palonosetron (Akynzeo\u2122) capsules \u2013 A report of two cases and a solution"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0995-1094","authenticated-orcid":false,"given":"Kevin","family":"Behbahany","sequence":"first","affiliation":[{"name":"Pharmacy Department, Providence Sacred Heart Hospital, Spokane, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Bubalo","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Oregon Health and Science University Hospital, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,25]]},"reference":[{"key":"bibr1-1078155220965671","unstructured":"Helsinn Birex Pharmaceuticals. Akynzeo (package insert). Dublin, Ireland, 2016."},{"key":"bibr2-1078155220965671","unstructured":"National Comprehensive Cancer Network (NCCN). Antiemesis (version 2.2020), www.nccn.org\/professionals\/physician_gls\/pdf\/antiemesis.pdf (2020, accessed 24 June 2020."},{"key":"bibr3-1078155220965671","doi-asserted-by":"publisher","DOI":"10.1592\/phco.31.2.164"},{"key":"bibr4-1078155220965671","unstructured":"U.S. Food and Drug Administration Center for Drug Evaluation and Research. Akynzeo: Clinical Pharmacology and Biopharmaceutics Review. Application no. 205718Orig1s000, 30 May 2014."},{"key":"bibr5-1078155220965671","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1338"},{"key":"bibr6-1078155220965671","unstructured":"Helsinn Birex Pharmaceuticals. Aloxi (package insert). Dublin, Ireland, 2015."}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220965671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155220965671","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220965671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:23:59Z","timestamp":1777688639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155220965671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,25]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/1078155220965671"],"URL":"https:\/\/doi.org\/10.1177\/1078155220965671","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,25]]}}}