{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:41:48Z","timestamp":1777934508020,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chemotherapy has been associated with a theoretical risk of hepatitis C virus (HCV) reactivation. However, little is known about the amplitude of viral replication and the incidence of subsequent hepatic exacerbation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We aimed to describe the occurrence of hepatitis flare and HCV reactivation at our center. We included, over a period of 5\u2009years, adult patients with chronic HCV receiving intravenous chemotherapy. We excluded patients with undetectable HCV RNA, hepatocellular carcinoma, liver metastases or other etiologies of hepatic disease. The primary objective was to identify hepatic flares (elevation of alanine aminotransferase 3 times above the upper limit of normal). Secondary objectives were to assess viral reactivation (HCVr, HCV-RNA \u22651 log10 IU\/mL when compared to baseline value), hepatic decompensation, mortality and the impact on the chemotherapy. Descriptive statistics were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 11 patients with chronic HCV were identified among the 5761 oncology patients. Five patients experienced a hepatic flare with median maximal ALT value of 139\u2009U\/L (IQR 133-237). Only 2 patients met criteria for HCVr with a median RNA increase of 1.16 log IU\/mL (IQR 1.1-1.2). One patient presented with both HCVr and a hepatic flare. Only one patient required chemotherapy discontinuation following hepatic flare. No hepatic decompensation or related mortality were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified a very small number of HCV cases among our population. We observed HCVr and hepatic flares, but only one consequence on cancer treatment. Nonetheless, HCV screening is encouraged among patients undergoing chemotherapy to allow close follow-up of hepatic function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220969797","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T03:59:23Z","timestamp":1604289563000},"page":"1815-1820","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Risks of hepatitis C virus reactivation in a real-life population of oncology patients treated in an academic center"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7661-0882","authenticated-orcid":false,"given":"Catherine-Audrey","family":"Boutin","sequence":"first","affiliation":[{"name":"Department of Microbiology, Infectious diseases and Immunology of the University of Montreal, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-0944","authenticated-orcid":false,"given":"Jean-Philippe","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"},{"name":"CHUM Research Center, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Martel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Canada"},{"name":"CHUM Research Center, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Doucet","sequence":"additional","affiliation":[{"name":"CHUM Research Center, Montreal, Canada"},{"name":"Service of Hematology and Oncology, Department of Medicine, CHUM, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Martel-Laferri\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious diseases and Immunology of the University of Montreal, Montreal, Canada"},{"name":"CHUM Research Center, Montreal, Canada"},{"name":"Service of Microbiology and Infectious diseases, CHUM, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"bibr1-1078155220969797","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29344"},{"key":"bibr2-1078155220969797","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.031"},{"key":"bibr3-1078155220969797","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0212-4"},{"key":"bibr4-1078155220969797","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.1"},{"key":"bibr5-1078155220969797","doi-asserted-by":"publisher","DOI":"10.1177\/1078155217734626"},{"key":"bibr6-1078155220969797","author":"Trubnikov M","year":"2011","journal-title":"CCDR"},{"key":"bibr7-1078155220969797","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.6437"},{"key":"bibr8-1078155220969797","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.7.2073-2075.1998"},{"key":"bibr9-1078155220969797","unstructured":"Prevention and treatment of cancer-related infection, National Comprehensive Cancer Network (NCCN) Guidelines version 1.2020, https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/infections.pdf (accessed 16 October 2020)."}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220969797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1078155220969797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155220969797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:24:06Z","timestamp":1777688646000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155220969797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/1078155220969797"],"URL":"https:\/\/doi.org\/10.1177\/1078155220969797","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]}}}