{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:53:38Z","timestamp":1782410018625,"version":"3.54.5"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gemcitabine is a nucleoside analog and pyrimidine antimetabolite that inhibits RNA synthesis, currently approved for use to treat a variety of cancers, among which ovarian cancers. Gemcitabine is considered relatively safe and it is generally well tolerated, with rarely reported cardiac side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report a case of gemcitabine induced dilated cardiomyopathy in a 41-year-old woman receiving gemcitabine as second line treatment for platinum-resistant ovarian cancer without pre-existing hypertension or significant cardiac history. Management and Outcome: The patient presented with clinical symptoms and laboratory and imaging results suggestive of congestive cardiac failure, with a left ventricular ejection fraction of 15%. Gemcitabine administration was stopped and Furosemide with ACE-inhibitors and Beta-blocker agents were initiated. At that point the clinical situation improved: symptoms and findings disappeared with gemcitabine cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our case demonstrated for the first time objective evidence for dilated cardiomyopathy induced by gemcitabine in a young patient with platinum-resistant ovarian cancer without pre-existing significant cardiac history. Although rare, gemcitabine-induced cardiotoxicity should be promptly recognized in order to take appropriate measures to manage it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220982044","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T11:26:20Z","timestamp":1612956380000},"page":"1542-1547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Gemcitabine-induced dilated-cardiomyopathy in patient with platinum-refractory ovarian-cancer: A case report and literature review"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7313-7732","authenticated-orcid":false,"given":"Lucrezia","family":"Raimondi","sequence":"first","affiliation":[{"name":"University of Rome Sapienza, Aprilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Maria","family":"Raimondi","sequence":"additional","affiliation":[{"name":"eCampus University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Rossi","sequence":"additional","affiliation":[{"name":"UOC Territorial Oncology of Aprilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachele","family":"Lazzeroni","sequence":"additional","affiliation":[{"name":"Sant'Andrea University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pietranera","sequence":"additional","affiliation":[{"name":"Centro Medico Diagnostico Salus, Civitavecchia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Di Benedetto","sequence":"additional","affiliation":[{"name":"BIOS SpA, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gozzi","sequence":"additional","affiliation":[{"name":"University of Rome Sapienza, Aprilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-6274","authenticated-orcid":false,"given":"Gian Paolo","family":"Spinelli","sequence":"additional","affiliation":[{"name":"University of Rome Sapienza, Aprilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"bibr1-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-220"},{"key":"bibr2-1078155220982044","first-page":"3","volume":"22","author":"Plunkett W","year":"1995","journal-title":"Semin Oncol"},{"key":"bibr3-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199803000-00001"},{"key":"bibr4-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00331.x"},{"key":"bibr5-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.8.1535"},{"key":"bibr6-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2767-7"},{"key":"bibr7-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600780"},{"key":"bibr8-1078155220982044","first-page":"40","volume":"27","author":"Ozols RF.","year":"2000","journal-title":"Semin Oncol"},{"key":"bibr9-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"bibr10-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh031"},{"key":"bibr11-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2001.11(Suppl.1)SUP1039.x"},{"key":"bibr12-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309396"},{"key":"bibr13-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.18"},{"key":"bibr14-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.121"},{"key":"bibr15-1078155220982044","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2006.n.039"},{"key":"bibr16-1078155220982044","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2005.n.004"},{"key":"bibr17-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx819"},{"key":"bibr18-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310221"},{"key":"bibr19-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1461"},{"key":"bibr20-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.5400"},{"key":"bibr21-1078155220982044","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw106"},{"key":"bibr22-1078155220982044","doi-asserted-by":"crossref","unstructured":"Rabinovitz A, Lombardo M, Schinke CD, et al. 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