{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:32:49Z","timestamp":1780756369232,"version":"3.54.1"},"reference-count":14,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pulmonary toxicity causally related to Imatinib (IM) therapy is uncommon in patients with chronic myeloid leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 61-year-old patient with chronic myeloid leukemia was treated with IM at 400\u2009mg daily dose. One month within IM, he developed skin lesions and then acute dyspnea and non-productive cough. Chest radiograph and high-resolution lung computed tomography (CT) revealed bilateral reticulonodular infiltration in both lungs. According to Naranjo's algorithm, the causality relationship with the drug is probable with a score of 7. The pharmacovigilance investigation was carried out and implicated IM Management &amp; outcome: IM was discontinued and started steroid therapy (Prednisolone\u00ae) at 1\u2009mg\/kg daily. Two weeks after, the dyspnea, and abnormal X-ray and CT findings are improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The early diagnosis of pulmonary toxicity related to IM therapy is needed to avoid further determinal effects of the drug.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1078155220984239","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:44:05Z","timestamp":1609289045000},"page":"1762-1765","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypersensitivity pneumonitis related to imatinib mesylate therapy in a patient with chronic myeloid leukemia"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-8565","authenticated-orcid":false,"given":"Faten","family":"Kallel","sequence":"first","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital of Sfax, The University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Kassar","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital of Sfax, The University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Maaloul","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hedi Chaker Hospital of Sfax, The University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Charfi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital of Sfax, The University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilia","family":"Ksouda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, The University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Elloumi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital of Sfax, The University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"bibr1-1078155220984239","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S1527"},{"key":"bibr2-1078155220984239","doi-asserted-by":"publisher","DOI":"10.4065\/78.12.1578"},{"key":"bibr3-1078155220984239","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.104"},{"key":"bibr4-1078155220984239","first-page":"935","volume":"8","author":"Cohen MH","year":"2002","journal-title":"Clin 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