{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:42:11Z","timestamp":1777934531835,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970122"],"award-info":[{"award-number":["81970122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY19H080006"],"award-info":[{"award-number":["LY19H080006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive production of inflammatory cytokines and multiple organs injury. Ruxolitinib, an oral selective JAK1\/2 inhibitor, has recently shown efficacy and safety in the treatment of secondary HLH, which may be an alternative to intensive chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report a case of a 2-year-old boy who presented to our institution with recurrent fever and acute renal failure. We made the diagnosis of Epstein-Barr virus related HLH based on the HLH-2004 protocol, and gave the treatment of ruxolitinib instead of etoposide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>The patient received dexamethasone and continuous renal replacement therapy due to renal failure, but he still had fever and anuria. Given that the use of etoposide may deteriorate renal function, ruxolitinib was administered instead of etoposide. After 5\u2009days of ruxolitinib treatment, the patient\u2019s fever was resolved and renal function also gradually recovered 14 days later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Currently, dexamethasone, etoposide and cyclosporine A are the main drugs in HLH treatment. However, cytotoxic chemotherapy can temporally deteriorate organ damage and induce serious myelosuppression, which makes clinicians hesitate to implement these regimens. Ruxolitinib has shown efficacy in treating HLH without much toxicity in clinical trials. Thus, we suggest that ruxolitinib constitutes a treatment option for secondary HLH complicated by severe renal damage which may reduce toxic effects compared with intense chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552211020821","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T02:47:35Z","timestamp":1622602055000},"page":"222-227","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Ruxolitinib is an alternative to etoposide for patient with hemophagocytic lymphohistiocytosis complicated by acute renal injury: A case report"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-2602","authenticated-orcid":false,"given":"Wei-Ling","family":"Yan","sequence":"first","affiliation":[{"name":"Hematology & Oncology Department, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Long","family":"Yang","sequence":"additional","affiliation":[{"name":"Hematology & Oncology Department, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen-Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hematology & Oncology Department, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Hematology & Oncology Department, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"bibr1-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.73"},{"key":"bibr2-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127"},{"key":"bibr3-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-019-00299-3"},{"key":"bibr4-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26264"},{"key":"bibr5-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02936-4"},{"key":"bibr6-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30184-X"},{"key":"bibr7-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000352"},{"key":"bibr8-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0217-z"},{"key":"bibr9-10781552211020821","doi-asserted-by":"publisher","DOI":"10.5414\/CN109196"},{"key":"bibr10-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788349"},{"key":"bibr11-10781552211020821","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401867"},{"key":"bibr12-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-684399"},{"key":"bibr13-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000761"},{"key":"bibr14-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25063"},{"key":"bibr15-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017007526"},{"key":"bibr16-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-003-0894-9"},{"key":"bibr17-10781552211020821","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.828358"},{"key":"bibr18-10781552211020821","unstructured":"Darazam IA, Sami R, Ghadir M, et al. Hemophagocytic [corrected] lymphohistiocytosis associated with nephrotic syndrome and multi-organ failure.\n                      Iranian Journal of Kidney Diseases\n                      2012; 6: 467."},{"key":"bibr19-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.7.1853"},{"key":"bibr20-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.03.016"},{"key":"bibr21-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2018.07.006"},{"key":"bibr22-10781552211020821","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30156-5"},{"key":"bibr23-10781552211020821","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.253781"},{"key":"bibr24-10781552211020821","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.222471"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552211020821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552211020821","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552211020821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:25:03Z","timestamp":1777688703000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552211020821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/10781552211020821"],"URL":"https:\/\/doi.org\/10.1177\/10781552211020821","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}