{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:12:50Z","timestamp":1790118770989,"version":"4.0.1"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Capecitabine is an antimetabolite antineoplastic agent widely used in the treatment gastrointestinal cancers. The common frequently reported cutaneous adverse drug reaction associated with capecitabin are a palmar-plantar erythrodysesthesia syndrome, rash and hyperpigmentation. This case reports a capecitabine-induced palmar hypopigmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report the case of a 74-years old patient with jejunum adenocarcinoma treated by capecitabine. The patient developed a pseudo-vitiligo after 2 cycles capecitabine and without history of cutaneous disorders. The skin lesions were characterized with skin hypopigmentation on both hands. Management and outcome: The hypopigmentation slowly recovered after capecitabine discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first described case of pseudo-vitiligo induced by capecitabine. This impressive but non-severe adverse effect should be known by oncologists and oncology pharmacists to reassure the patients in particular about the possible recovery after discontinuation of capecitabine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552211027936","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T02:14:45Z","timestamp":1625710485000},"page":"247-249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of palmar hypopigmentation induced by capecitabine in a gastrointestinal cancer patient"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-8258","authenticated-orcid":false,"given":"Julian","family":"Gratiaux","sequence":"first","affiliation":[{"name":"Department of Pharmacy, CHU Reims, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Gossery","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, CHU Reims, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirine","family":"Rezzag-Mahcene","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Reims, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Botsen","sequence":"additional","affiliation":[{"name":"Oncology-day Hospital, CHU Reims, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Visseaux","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Reims, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Slimano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, CHU Reims, Reims, France"},{"name":"Faculty of 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