{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:42:53Z","timestamp":1777934573598,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Febrile neutropenia (FN) is a life-threatening complication of Docetaxel-based chemotherapy regimens (DBRs). Prophylactic granulocyte-colony stimulating factor (G-CSF) can reduce the risk of FN. This study investigated the effect of G-CSF on FN in patients receiving DBRs for breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients treated between 2015 and 2017 were identified from the hospital\u2019s pharmacy database and their medical records were examined retrospectively. Data from patients\u2019 first four cycles of DBR were collected. FN rate, FN associated length of hospital stay (FN-LOS), and chemotherapy dose modification\/delay due to FN were compared between patients who did (G-CSF group) or did not (non-GCSF group) receive prophylactic G-CSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 276 included patients, 83.3% received a DBR as adjuvant or neoadjuvant therapy, and 50% received docetaxel as combination therapy. Prophylactic G-CSF was administered with the first cycle of a DBR in 69.9% of patients who were significantly less likely to experience FN compared to the non-G-CSF group (6.2% vs. 15.7%; odds ratio: 0.36 [95% CI: 0.16\u20130.82]; p\u2009=\u20090.020). Collectively and after the 4 DBR treatment cycles, FN rate (4.8 vs. 8.5; odds ratio: 0.54 [95% CI: 0.30\u20130.97]; p\u2009=\u20090.043) and the mean FN-LOS (3.55 vs. 5.28\u2009days; t\u2009=\u2009\u20132.22; p\u2009=\u20090.037) were reduced in the G-CSF group. There was no difference in DBR dose delay\/reduction between both groups in cycles 2\u20134.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients receiving DBRs for breast cancer, prophylactic G-CSF significantly reduced both the rate of FN and duration of hospitalization for FN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552211030974","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T10:20:15Z","timestamp":1627986015000},"page":"1681-1686","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of granulocyte-colony stimulating factor on docetaxel-induced febrile neutropenia in patients with breast cancer"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-0207","authenticated-orcid":false,"given":"Jamal","family":"Zekri","sequence":"first","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"},{"name":"College of Medicine, Al-Faisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azhar","family":"Nawaz","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-5106","authenticated-orcid":false,"given":"Haleem","family":"Rasool","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Ahmad","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam","family":"Abdel Rahman","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-9342","authenticated-orcid":false,"given":"Reyad","family":"Dada","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab Mosaad","family":"Abdelghany","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"},{"name":"National Cancer Institute, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Farag","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"},{"name":"Department of Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refaei Belal","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"},{"name":"Department of Clinical oncology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Youssef","family":"Deibas","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Kamal","family":"Kamel","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital & Research Center, Jeddah, Saudi 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