{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:42:29Z","timestamp":1777934549804,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to evaluate the frequency of nail disorders and the presence of fungi on the nails of the hands and feet of patients with hand-foot syndrome secondary to treatment with paclitaxel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study, carried out from October 2018 to December 2019, which included 81 patients undergoing treatment for breast cancer using paclitaxel and had signs and or symptoms of hand-foot syndrome with or without nail disorders. The data were collected through interviews guided by a structured questionnaire, information from medical records and reports of mycological exams.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average age of women was 54.7\u2009\u00b1\u20097.4 years. Nail disorders occurred in 69 patients (85.2%), and of these, 43 (62.3%) were positive for fungi. The fungi were yeasts ( n\u2009=\u200938; 69%), dermatophytes ( n\u2009=\u200915; 27.2%) and non-dermatophyte filamentous fungi ( n\u2009=\u20098; 14.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nail disorders were the most frequent manifestations in patients with hand-foot syndrome treated with paclitaxel and occurred in 85.2% of them. It was evidenced that fungi are present on the nails of these patients and can occur in up to 65.28%. The most prevalent fungi were Candida and Trichophyton. The nail lesion was associated with the type of treatment protocol used by the patient. The results of the study point to the need to select safe management alternatives for patients, so they can prevent nail lesions and prevent the proliferation of fungi, consequently reducing negative life impact during treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552211043752","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T07:49:12Z","timestamp":1632988152000},"page":"1798-1806","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hand-foot syndrome and nail disorders secondary to treatment with paclitaxel: Is there a relationship with the presence of fungi?"],"prefix":"10.1177","volume":"28","author":[{"given":"Paulina Patente","family":"Pereira","sequence":"first","affiliation":[{"name":"Post-graduate Program in Health Sciences, Faculty of Medicine, Federal University of Uberl\u00e2ndia (UFU), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio","family":"Nunes Filho","sequence":"additional","affiliation":[{"name":"Multiprofessional Residency Program, Faculty of Medicine, UFU, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomaz de Aquino","family":"Moreira","sequence":"additional","affiliation":[{"name":"Clinical Analysis Laboratory, Hospital das Cl\u00ednicas, UFU, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciv\u00e2nia","family":"Duarte Silva Malvino","sequence":"additional","affiliation":[{"name":"Clinical Analysis Laboratory, Hospital das Cl\u00ednicas, UFU, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2230-203X","authenticated-orcid":false,"given":"L\u00facio Borges","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics, UFU, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-5754","authenticated-orcid":false,"given":"Reginaldo","family":"dos Santos Pedroso","sequence":"additional","affiliation":[{"name":"Post-graduate Program in Health Sciences, Faculty of Medicine, Federal University of Uberl\u00e2ndia (UFU), Brazil"},{"name":"Technical School of Health, UFU, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"\u00c2ngela Ribeiro","sequence":"additional","affiliation":[{"name":"Multiprofessional Residency Program, Faculty of Medicine, UFU, Brazil"},{"name":"Clinical Pharmacy, Hospital das Cl\u00ednicas, UFU, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"bibr1-10781552211043752","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1590\/1981.81222017000100010","volume":"12","author":"Ara\u00fajo Neto LA","year":"2017","journal-title":"Bol Mus Para Em\u00edlio Goeldi. 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