{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:29Z","timestamp":1777934609641,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atypical chronic myeloid leukaemia (aCML) is a rare chronic myeloproliferative disorder with a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>This case report presents two cases of male geriatric patients, both referred from primary care in rural areas and received at an urban clinic in a tertiary care hospital on separate instances. The first patient complained of low-grade fever (on\/off), generalized body aches, rapid weight loss and shortness of breath for the last 2 months. The second patient arrived pale looking with symptoms of generalized body aches, dizziness and anorexia. Both patients were diagnosed to have aCML according to the World Health organization criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management &amp; outcome<\/jats:title>\n                    <jats:p>Both the patients were from a low economic bracket and were treated with Hydroxyurea a relatively economic medicine successfully. The follow-up lasted for 12 months in both cases. No progression to acute myeloid leukaemia (AML) or relapse was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case report shows the promising results of Hydroxyurea in treating aCML and can be a cost effective alternate to other expensive treatments (allogeneic hematopoietic stem cell transplantation) and expensive medicines in lower and middle-income countries especially for resource-limited patients. These two cases show promising evidence for further studies to evaluate and conduct pharmaco-economic evaluations as well as clinical trials to compare hydroxyurea with other available alternative treatments for an affordable therapeutic option towards prevention of relapse and disease free survival after aCML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552211073518","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T07:09:50Z","timestamp":1641971390000},"page":"1014-1018","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydroxyurea- a cost effective treatment in developing countries for Atypical Chronic Myeloid Leukemia (aCML): Case Report of Two Patients"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9789-0270","authenticated-orcid":false,"given":"Zair","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Lady Reading Hospital, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7282-471X","authenticated-orcid":false,"given":"Ayesha","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Practice and Policy, School of Pharmacy, University of Nottingham, University park Campus, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiqa","family":"Zahoor","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hayatabad Medical Complex, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftikhar","family":"Ali","sequence":"additional","affiliation":[{"name":"Paraplegic Center, Hayatabad, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Mamoon","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Internal Medicine trainee, University Hospitals of Leicester, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashida","family":"Bibi","sequence":"additional","affiliation":[{"name":"Lecturer in Clinical Pharmacy, Abbottabad University of Science and Technology, Abbottabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"bibr1-10781552211073518","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb06734.x"},{"key":"bibr2-10781552211073518","first-page":"14","volume":"22","author":"Drozd-Soko\u0142owska JE","year":"2018","journal-title":"Contemp Oncol (Pozn)"},{"key":"bibr3-10781552211073518","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-693630"},{"key":"bibr4-10781552211073518","first-page":"1566","volume":"91","author":"Breccia M","year":"2006","journal-title":"Haematologica"},{"key":"bibr5-10781552211073518","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-114885"},{"key":"bibr6-10781552211073518","doi-asserted-by":"publisher","DOI":"10.1177\/2040620715607416"},{"key":"bibr7-10781552211073518","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.11.2915"},{"key":"bibr8-10781552211073518","unstructured":"Gotlib J. 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