{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:23Z","timestamp":1787019083732,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Imatinib mesylate (IM) treatment adherence is a challenge, especially in an economic-social population neglected from developing countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To create a new complementary audiovisual educational intervention model to improve IM treatment adherence of CML patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two adherence verification methods were applied before and after intervention: modified Morisky-Green test and molecular responses (BCR-ABL transcripts quantification). Adherence estimates were calculated using univariate and multivariate component analysis (MCA) for the socio-demographic and clinical characteristics of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Modified Morisky-Green test results demonstrated a substantial increase of CML patient adherence from 23% (pre-film) to 65% (post-film). Greater improvement was obtained for patients presenting major molecular response (MMR) from 38% (pre-film) to 60% (post-film). Although slight gain for complete molecular response (CMR) from 23% (pre-film) to 26% (post-film) was achieved, it represents a total tumour regression. MCA identified that females &lt;50 years-old, using less than two medications (no disease associated) and CMR condition were the most benefited with intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Audiovisual educational intervention was an effective complementary pro-adherence model, activating patient memory and improving IM treatment adherence. Although this intervention shows effective, not all patients responded as expected, being necessary a combination of educational and clinical interventions to improve IM adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552211073894","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T10:25:10Z","timestamp":1642587910000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pro-adherence complementary audiovisual educational intervention model for chronic myeloid leukemia patients treated with imatinib mesylate"],"prefix":"10.1177","volume":"29","author":[{"given":"Adriana do Prado","family":"Barbosa","sequence":"first","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Rodrigues Martins","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3940-6396","authenticated-orcid":false,"given":"Nathalie de Lourdes Souza","family":"Dewulf","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilsione Jos\u00e9","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Neri Meira de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Andrade","family":"Lemes","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna Medeiros Barros da","family":"Cunha","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-1678","authenticated-orcid":false,"given":"Alessandro de Carvalho","family":"Cruz","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos da","family":"Cunha","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30491-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4065\/81.7.973"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441402"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.26.15_suppl.6598"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200725060-00004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V110.11.4553.4553"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-196543"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-309807"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22019"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suponc.2011.08.001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/60.7.657"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20004"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3087"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V116.21.1235.1235"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.348"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V114.22.2209.2209"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.2.6.757"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200306010-00022"},{"key":"e_1_3_3_20_2","unstructured":"WHO. 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