{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:34:35Z","timestamp":1778708075380,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osimertinib is an approved therapy for patients with a Thr790met (T790M) mutation diagnosed with non-small cell lung cancer (NSCLC) that progresses during epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. However, in 7\u201313% of patients, drug-related side effects lead to discontinuation of osimertinib treatment. In such cases, osimertinib desensitization is a treatment option that can be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 59-year-old female patient, who was followed up with the diagnosis of stage 4 NSCLC, was consulted to the allergy clinic because of urticaria. The patient developed urticaria plaques 20\u2005h after the third dose of osimertinib tablet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management &amp; outcome<\/jats:title>\n                    <jats:p>With the diagnosis of osimertinib-induced urticaria, desensitization was planned for the patient. Treatment was started with a dose of 0.1\u2005mg\/day osimertinib. The procedure was completed in approximately 50 days, and a dose of 80\u2005mg\/day was reached with antihistamine suppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Here, a successful osimertinib desensitization in a patient with a history of osimertinib-related type 1 allergic reaction is reported. Osimertinib desensitization is a treatment option that should be considered in cases where treatment has to be ceased due to drug-related side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552221075809","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T09:41:43Z","timestamp":1642758103000},"page":"1454-1457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful desensitization under antihistamine suppression in a case with urticaria due to osimertinib"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-9255","authenticated-orcid":false,"given":"G\u00fcrg\u00fcn Tu\u011f\u00e7e","family":"Vural Solak","sequence":"first","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurtulu\u015f","family":"Aksu","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa","family":"Topel","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"\u00c7uhadar Er\u00e7elebi","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Ye\u015filkaya","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eenay","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6zde","family":"K\u00f6yc\u00fc Buhari","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lkay","family":"Koca Kalkan","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hale","family":"Ate\u015f","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakine","family":"Nazik Bah\u00e7ecio\u011flu","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, University of Health Sciences, Atat\u00fcrk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"bibr1-10781552221075809","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530"},{"key":"bibr2-10781552221075809","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044238"},{"key":"bibr3-10781552221075809","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713137"},{"key":"bibr4-10781552221075809","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612674"},{"key":"bibr5-10781552221075809","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4429-20"},{"key":"bibr6-10781552221075809","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-018-0608-7"},{"key":"bibr7-10781552221075809","first-page":"961","volume":"46","author":"Watanabe H","year":"2019","journal-title":"Gan To Kagaku 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