{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:46:35Z","timestamp":1788281195985,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Management of elderly patients with cancer has become a global issue. We investigated the safety and tolerability of lenvatinib in hepatocellular carcinoma (HCC) patients \u226580 years old.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated 61 HCC patients and divided them into 2 groups: an elderly group (n\u2009=\u200913, \u226580 years old) and a younger group (n\u2009=\u200948, &lt;80 years old). We compared the adverse events (AEs), administration period, dose intensity, objective response, and progression-free survival (PFS) between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The discontinuation of lenvatinib due to AEs was more frequent in the elderly group (8\/13, 61.5%) than in the younger group (10\/48, 20.8%) (P\u2009=\u20090.0043). Fatigue and appetite loss accounted for half of the cases discontinued due to AEs in the elderly group. The elderly group had a significantly lower 8-week-delivered dose intensity\/body surface area ratio (147.2) and 8-week-relative dose intensity (50.0%) than those in the younger group (267.4, 67%) (P\u2009=\u20090.003, 0.029). The objective response rate was significantly lower in the elderly group (15.4%) than in the younger group (61.5%) (P\u2009=\u20090.021). The PFS in the elderly group tended to be shorter than that in the younger group (P\u2009=\u20090.058, hazard ratio [HR] 1.98). The modified albumin-bilirubin (mALBI) grade (hepatic function) (HR, 2.60; P\u2009=\u20090.01) and objective response (HR, 0.41; P\u2009=\u20090.011) were independently associated with the PFS in the multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The management of AEs is crucial for adherence and maintaining the dose intensity of lenvatinib in elderly HCC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552221077039","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T09:19:11Z","timestamp":1643879951000},"page":"626-636","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Poor tolerability of lenvatinib in elderly patients \u226580 years old with hepatocellular carcinoma: A multicenter observational study"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-4485","authenticated-orcid":false,"given":"Akiyoshi","family":"Kinoshita","sequence":"first","affiliation":[{"name":"the Jikei University Daisan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"the Jikei University Daisan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyuki","family":"Osawa","sequence":"additional","affiliation":[{"name":"the Jikei University Daisan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Akasu","sequence":"additional","affiliation":[{"name":"the Jikei University Kashiwa Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"the Jikei University Kashiwa Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Ueda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Minato, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Saeki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Minato, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Minato, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Koike","sequence":"additional","affiliation":[{"name":"the Jikei University Daisan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Saruta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Minato, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.2996"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_3_3_4_2","unstructured":"Ministry of Health Labor and Welfare 2019. 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