{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:42Z","timestamp":1777934622666,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>10\u201316% of non-small cell lung cancer (NSCLC) cases have the epidermal growth factor receptor (EGFR) amplified and\/or mutated. Studies show that EGFR tyrosine kinase inhibitors (TKIs) significantly prolong progression-free survival (PFS) in patients with advanced NSCLC compared to those treated with platinum-based chemotherapy (CT) doublets. Our aim is to perform a real-world survival analysis of patients treated with TKI as first-line therapy at the Hospital of Leon (CAULE) in Spain. The impact on global survival rates and responses to clinical and histopathological factors were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients diagnosed with EGFR-mutated NSCLC who received treatment with EGFR-TKI in the Department of Oncology at the University of Leon Health Center complex between March 2011 and June 2018. Data was analyzed with Kaplan-Meier and Cox regression models to show overall survival (OS), progression-free survival (PFS), and the associated variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>53 patients were included in the study, 50% (n\u2009=\u200927) were treated with gefitinib, 32% (n\u2009=\u200918) with erlotinib and 10% (n\u2009=\u20096) with afatinib. The median OS and PFS were 27.7 months (95% CI: 21\u201333.8 months) and 18 months (95% CI 14.25\u201321.89 months), respectively. The variables associated with OS and with PFS were exon19 deletion as a protective factor and presence of extrathoracic metastasis as a risk factor. The most frequent adverse effects were rash, diarrhea, asthenia, and conjunctivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real-world analysis of this data confirms that treatment with TKI is beneficial for patients diagnosed with EGFR-mutated NSCLC. Our OS outcomes were similar to those reported in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552221085253","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T04:45:32Z","timestamp":1647837932000},"page":"854-860","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["EGFR-mutated advanced lung cancer. Data from a single institution, the Hospital of Leon, in Spain"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-6605","authenticated-orcid":false,"given":"Irene","family":"Delgado Sillero","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea","family":"Lopetegui Lia","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Felipe","family":"S\u00e1nchez Cousido","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Rojas Piedra","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"T\u00e1vara Silva","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Garrido Onecha","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soledad","family":"Medina Valdivieso","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"Alonso Horcajo","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"D\u00edez Tasc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"L\u00f3pez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Casta\u00f1\u00f3n L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Leon Health Center complex, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Pedraza 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