{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:05:34Z","timestamp":1790301934442,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Adverse Drug Reaction Monitoring Center of Shandong province","award":["2021SDADRKY04"],"award-info":[{"award-number":["2021SDADRKY04"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF), is commonly used to prevent and\/or treat neutropenia caused by tumor chemotherapy and radiotherapy with reduced clearance, increased plasma half-life, sustained biologic activity, and good safety. PEG-rhG-CSF anaphylaxis was rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 55-year-old male Non-Hodgkin lymphoma patient appeared with chest tightness, increased heart rate, and decreased blood pressure after taking PEG-rhG-CSF used as a primary treatment for neutropenia caused by chemoradiotherapy. The patient\u2019s anaphylaxis is likely due to PEG-rhG-CSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>0.9% sodium chloride 250\u2005mL and dexamethasone sodium phosphate injection 5\u2005mg were carried out. After close observation, the symptoms were improved. Two months later, the patient was readministered with PEG-rhG-CSF and anaphylaxis reoccurred. After the last contact with PEG-rhG-CSF, the patient was prescribed rhG-CSF for many times and did not experience any adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>PEGylated drugs are not free of risk and immune-mediated adverse events are of concern. PEG is a substance capable of triggering an immune response. The mechanism of PEG involved IgE-mediated anaphylaxis and non-IgE-mediated anaphylaxis, and requires further research. PEGylated drugs are not free of risk and immune-mediated adverse events are of concern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552221112323","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T02:13:20Z","timestamp":1657764800000},"page":"727-730","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Anaphylaxis caused by pegylated recombinant human granulocyte colony-stimulating factor"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-0841","authenticated-orcid":false,"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"The Second Hospital of Shandong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qi","sequence":"additional","affiliation":[{"name":"The 960th Hospital of PLA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juandong","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Shandong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt226"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-015-0127-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.9.9S.32888"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/03602539608994020"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03575-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100472"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2017.05.04"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08364-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.2160"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_2_12_2","first-page":"365","article-title":"Multiple drug allergy due to hypersensitivity to polyethylene glycols of various molecular weights","volume":"25","author":"Badiu I","year":"2015","unstructured":"Badiu I, Guida G, Heffler E, et al. Multiple drug allergy due to hypersensitivity to polyethylene glycols of various molecular weights. 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