{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:58Z","timestamp":1777934638415,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The increasing use of oral anticancer agents over the past years has necessitated changes in monitoring toxicities to ensure patients\u2019 adherence and tolerance at home. The aim of this study was to describe nurses\u2019 interventions and medical changes after alerts triggered by a web-based platform designed to support the management of oral anticancer agents-related toxicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients undergoing oral anticancer agents in a cancer center from September 2018 to September 2019 (excluding hormonal therapy). In this cancer center, the standard of care included symptoms\u2019 collections for 1 month thanks to a web platform based on patient-reported outcomes. Patients had to fill a weekly questionnaire (Q1 to Q4). The web-based platform triggered orange alerts when patients reported moderate symptoms and red alerts when severe toxicities were declared. The rate of orange and red alerts, the rate of patients with medical changes consecutively to an orange or a red alert, and the different types of nurses\u2019 interventions and medical changes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 524 patients were extracted but the final number of 436 patients were included in this study and 1488 questionnaires were filled in. More than 90% of patients declared that they took their medication as prescribed. Up to 60% of patients recorded all grade symptoms, including 8% of patients who recorded Grades 3\u20134 symptoms during the month, mostly anorexia, fatigue, and diarrhea. The web platform system triggered 700 orange and 212 red alerts: 305\/700 (44%) of orange alerts resulted in nurses\u2019 interventions, most frequently phone counseling (78%), and 65\/212 (31%) of red alerts resulted in medical changes, most frequent treatment interruptions (48%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implementing an e-health (electronic-health) system can be helpful for monitoring symptoms in patients under oral anticancer agents, enhancing that this organization should be a standard of care in every cancer centers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552221117731","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T03:22:35Z","timestamp":1659928955000},"page":"278-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Smartphone-based application and nurses\u2019 interventions for symptoms monitoring in patients treated with oral anticancer agents: A 1-year follow-up in a tertiary cancer center"],"prefix":"10.1177","volume":"32","author":[{"given":"Laura","family":"Porcher","sequence":"first","affiliation":[{"name":"Centre Georges Fran\u00e7ois Leclerc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Perron","sequence":"additional","affiliation":[{"name":"Centre Georges Fran\u00e7ois Leclerc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Blanc","sequence":"additional","affiliation":[{"name":"Centre Georges Fran\u00e7ois Leclerc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cour\u00e8che-Guillaume","family":"Kaderbhai","sequence":"additional","affiliation":[{"name":"Centre Georges Fran\u00e7ois Leclerc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zo\u00e9","family":"Tharin","sequence":"additional","affiliation":[{"name":"Centre Georges Fran\u00e7ois Leclerc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-7730","authenticated-orcid":false,"given":"Antonin","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Centre Georges Fran\u00e7ois Leclerc"},{"name":"INSERM U1231, University of Burgundy Franche-Comt\u00e9, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-9108","authenticated-orcid":false,"given":"Matthieu","family":"Gallet","sequence":"additional","affiliation":[{"name":"Centre Georges Fran\u00e7ois Leclerc"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600591"},{"key":"e_1_3_2_3_2","unstructured":"Les th\u00e9rapies cibl\u00e9es dans le traitement du cancer en 2015 - \u00c9tat des lieux et enjeux - Ref : APDEMOMED16 [Internet]. 2015 [accessed 2 January 2020]. 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