{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:49:27Z","timestamp":1780087767793,"version":"3.54.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Combined immune checkpoint inhibitor therapy has been successfully used in the treatment of several malignancies. Adverse effects with the combination therapy may be more severe than the ones seen with single immune checkpoint inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a unique case of a 59-year-old man of dark skin complexion who underwent treatment with intravenous ipilimumab\u2013nivolumab every 3 weeks for metastatic malignant melanoma. After three cycles of this therapy, he developed extensive skin depigmentation that within 6 weeks, affected nearly the entire skin surface, along with progressive poliosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>Ipilimumab\u2013nivolumab therapy was subsequently discontinued due to grade 3 enterocolitis requiring high-dose steroids and intravenous infliximab. About six months later, imaging studies showed a relapse of malignant melanoma. At that juncture, vitiligo affected the total body surface area, resembling albinism, along with near-total poliosis and significant photosensitivity. Pembrolizumab was tried but had to be stopped after three cycles due to the reoccurrence of grade 3 enterocolitis. Progression of malignant melanoma with new brain, lung, liver, subcutaneous, and colonic metastases led to the patient's demise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We report a unique case of severe vitiligo and poliosis that involved total body surface area in a Caucasian man with dark complexion, resembling albinism. Further studies are warranted to evaluate the severity of dermatologic side effects with combination immune checkpoint inhibitor therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231154460","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T03:01:17Z","timestamp":1676343677000},"page":"1278-1282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Widespread vitiligo and poliosis following ipilimumab\u2013nivolumab combination therapy"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-626X","authenticated-orcid":false,"given":"Khashayar","family":"Nemovi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Eisenhower Health, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8488-8312","authenticated-orcid":false,"given":"Arsia","family":"Jamali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Eisenhower Health, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyan","family":"Matinpour","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eisenhower Health, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-8394","authenticated-orcid":false,"given":"Constantin A","family":"Dasanu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Eisenhower Lucy Curci Cancer Center, Rancho Mirage, CA, USA"},{"name":"Department of Hematology and Oncology, UC San Diego Health System, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"bibr1-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"bibr2-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.677"},{"key":"bibr3-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr4-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.09.002"},{"key":"bibr5-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0483"},{"key":"bibr6-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718217115"},{"key":"bibr7-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000292"},{"key":"bibr8-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0769-3"},{"key":"bibr9-10781552231154460","doi-asserted-by":"publisher","DOI":"10.7150\/jca.17144"},{"key":"bibr10-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.02.018"},{"key":"bibr11-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1714"},{"key":"bibr12-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2017-000247"},{"key":"bibr13-10781552231154460","doi-asserted-by":"publisher","DOI":"10.2174\/1574886313666180730114309"},{"key":"bibr14-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19750"},{"key":"bibr15-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-018-0244-7"},{"key":"bibr16-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0336-3"},{"key":"bibr17-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.02.025"},{"key":"bibr18-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16311"},{"key":"bibr19-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100064"},{"key":"bibr20-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14678"},{"key":"bibr21-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001451"},{"key":"bibr22-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15354"},{"key":"bibr23-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15237"},{"key":"bibr24-10781552231154460","doi-asserted-by":"publisher","DOI":"10.3390\/immuno2020020"},{"key":"bibr25-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003689"},{"key":"bibr26-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07508-7"},{"key":"bibr27-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15345"},{"key":"bibr28-10781552231154460","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1915279"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552231154460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552231154460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552231154460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:27:56Z","timestamp":1777688876000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552231154460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1177\/10781552231154460"],"URL":"https:\/\/doi.org\/10.1177\/10781552231154460","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]}}}