{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:16Z","timestamp":1777934596671,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Rhizobium radiobacter<\/jats:italic>\n                      is a gram-negative, opportunistic phytopathogen that rarely causes human infections. We report two cases of\n                      <jats:italic toggle=\"yes\">Rhizobium radiobacter<\/jats:italic>\n                      central line-associated bloodstream infection (CLABSI) in allogeneic hematopoietic cell transplantation (alloHCT) recipients. We review previous reports and common microbiological characteristics associated with this organism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case reports<\/jats:title>\n                    <jats:p>\n                      Two adult males developed\n                      <jats:italic toggle=\"yes\">R. radiobacter<\/jats:italic>\n                      CLABSIs at day +81 and day +77 post-alloHCT. Patient one was asymptomatic on presentation while patient two was febrile. One patient had a polymicrobial infection, which has not been previously described. The presence of high-level ceftazidime resistance in both patients suggests third-generation cephalosporin resistance may be more common than previously recognized.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>\n                      For both patients, microbiologic clearance was achieved through peripherally inserted central catheter removal and initiation of intravenous cefepime. Antibiotic therapy was narrowed to oral levofloxacin for a total 14-day course from the time of first negative blood culture. There has been no subsequent recurrence of\n                      <jats:italic toggle=\"yes\">R. radiobacter<\/jats:italic>\n                      infection at 12 and 5 months of follow-up for patients one and two, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      These two cases add to the scant literature characterizing\n                      <jats:italic toggle=\"yes\">R. radiobacter<\/jats:italic>\n                      infection following alloHCT. Immunosuppressive agents for graft-versus-host disease prophylaxis may have predisposed these patients to\n                      <jats:italic toggle=\"yes\">R. radiobacter<\/jats:italic>\n                      infection. Our reports, and previously reported cases, suggest\n                      <jats:italic toggle=\"yes\">R. radiobacter<\/jats:italic>\n                      exhibits low virulence, mild symptom burden, and does not confer a high mortality risk. In the alloHCT setting, further accumulation of cases is needed to aid in understanding clinical features and characteristics of\n                      <jats:italic toggle=\"yes\">R. radiobacter<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231161826","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T02:56:30Z","timestamp":1678848990000},"page":"383-387","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Central line-associated\n                    <i>Rhizobium radiobacter<\/i>\n                    bloodstream infection in two allogeneic hematopoietic cell transplant recipients"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-3646","authenticated-orcid":false,"given":"Rachel E","family":"Hartman","sequence":"first","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig W","family":"Freyer","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilios","family":"Athans","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon R","family":"McCurdy","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle V","family":"Frey","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/16.1.112"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/380463"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.22.4.683-685.1985"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-6-839"},{"key":"e_1_3_2_6_2","first-page":"63","article-title":"Agrobacterium spp. isolated from clinical specimens","volume":"187","author":"Lautrop H","year":"1967","unstructured":"Lautrop H. Agrobacterium spp. isolated from clinical specimens. Acta Pathol Microbiol Scand1967; 187: 63\u201364.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.5.2.172-177.1977"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013500942"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00396.x"},{"key":"e_1_3_2_10_2","first-page":"31","article-title":"Catheter-related bacteremia caused by Agrobacterium radiobacter in a cancer patient: case report and literature review","volume":"6","author":"Paphitou NI","year":"2003","unstructured":"Paphitou NI, Rolston KVI. Catheter-related bacteremia caused by Agrobacterium radiobacter in a cancer patient: case report and literature review. 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