{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:15Z","timestamp":1777934595564,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008307","name":"Beckman Research Institute, City of Hope","doi-asserted-by":"publisher","award":["California Institute of Technology \u2013 City of Hop"],"award-info":[{"award-number":["California Institute of Technology \u2013 City of Hop"]}],"id":[{"id":"10.13039\/100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008307","name":"Beckman Research Institute, City of Hope","doi-asserted-by":"publisher","award":["City of Hope's Center for Cancer and Aging"],"award-info":[{"award-number":["City of Hope's Center for Cancer and Aging"]}],"id":[{"id":"10.13039\/100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA033572"],"award-info":[{"award-number":["P30CA033572"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA239373"],"award-info":[{"award-number":["U01CA239373"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-21-181-01-CTPS"],"award-info":[{"award-number":["RSG-21-181-01-CTPS"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM129863"],"award-info":[{"award-number":["R01GM129863"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Medication nonadherence continues to be challenging for allogeneic hematopoietic cell transplant (HCT) recipients. The risk and severity of chronic graft-versus-host disease (GVHD) are associated with low immunosuppressant concentrations (which can be improved with model-informed precision dosing (MIPD)) and with immunosuppressant nonadherence (which can be improved with acceptable interventions).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      With the goals of improving adherence and achieving therapeutic concentrations of immunosuppressants to eliminate GVHD, we characterized the feasibility of using the Medication Event Monitoring (MEMS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) Cap in adult HCT recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 27 participants offered the MEMS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Cap at the time of hospital discharge, 7 (25.9%) used it, which is below our a priori threshold of 70%. These data suggest the MEMS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Cap is not feasible for HCT recipients. The MEMS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Cap data were available for a median of 35 days per participant per medication (range: 7\u2013109 days). The average daily adherence per participant ranged from 0 to 100%; four participants had an average daily adherence of over 80%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      MIPD may be supported by MEMS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      technology to provide the precise time of immunosuppressant self-administration. The MEMS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Cap was used by only a small percentage (25.9%) of HCT recipients in this pilot study. In accordance with larger studies using less accurate tools to evaluate adherence, immunosuppressant adherence varied from 0% to 100%. Future studies should establish the feasibility and clinical benefit of combining MIPD with newer technology, specifically the MEMS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Button, which can inform the oncology pharmacist of the time of immunosuppressant self-administration.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231171607","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T14:13:54Z","timestamp":1683123234000},"page":"322-331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Immunosuppressant adherence in adult outpatient hematopoietic cell transplant recipients"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0795-497X","authenticated-orcid":false,"given":"Jeannine S","family":"McCune","sequence":"first","affiliation":[{"name":"Department of Hematologic Malignancies Translational Sciences, City of Hope, and Department of Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saro H","family":"Armenian","sequence":"additional","affiliation":[{"name":"Department of Population Sciences, City of Hope, and Department of Pediatrics, City of Hope Medical Center, Duarte, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryotaro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematologic Malignancies Translational Sciences, City of Hope, and Department of Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyue","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, City of Hope, Duarte, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G","family":"Kanakry","sequence":"additional","affiliation":[{"name":"Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mielcarek","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Center and Department of Medical Oncology, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Andrew and Peggy Cherng, Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald E","family":"Mager","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY, USA"},{"name":"Enhanced Pharmacodynamics, LLC, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"bibr1-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0339-2"},{"key":"bibr2-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.07.008"},{"key":"bibr3-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.107"},{"key":"bibr4-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30088-2"},{"key":"bibr5-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007535"},{"key":"bibr6-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0340-9"},{"key":"bibr7-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.04.026"},{"key":"bibr8-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2001.150306.x"},{"key":"bibr9-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.08.009"},{"key":"bibr10-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.14"},{"key":"bibr11-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703207"},{"key":"bibr12-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.27"},{"key":"bibr13-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199907270-00018"},{"key":"bibr14-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01983.x"},{"key":"bibr15-10781552231171607","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/15.4.459"},{"key":"bibr16-10781552231171607","unstructured":"Hoodin F.\n                      Psychological and behavioral correlates of medical adherence among adult bone marrow transplantation recipients\n                      . 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