{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T14:40:21Z","timestamp":1786804821097,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T00:00:00Z","timestamp":1683417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008130","name":"Helsinn Therapeutics","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100008130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Objective: The purpose of this study was to investigate the efficacy and safety of netupitant\/palonosetron (NEPA) for the prevention of chemotherapy-induced nausea and vomiting (CINV) for hematopoietic cell transplantation (HCT) patients receiving BEAM therapy. Study Design: This phase II, prospective, intention-to-treat, single-center, single-arm study involved 43 adult patients who received NEPA and dexamethasone for the prevention of CINV due to BEAM conditioning chemotherapy. An interim analysis, performed after 13 patients, determined utility versus futility, and supported continuation to full enrollment. Descriptive statistics were used to report complete response (CR), complete protection, incidence of emesis, and administration of rescue agents. A Kaplan\u2013Meier curve depicted time to first emesis and first rescue medication. Patients self-reported levels of daily nausea descriptively via a CINV Questionnaire. Results: By study end, 13 of 43 patients achieved a CR with an average of 10.6 emesis-free days (SD 0.95) over the 11-day observation period, with no emetic events in any patient during the acute\/chemotherapy phase. Nausea was well-controlled throughout the acute therapy phase (Day 1\u20136) and increased during the delayed phase (Day 7\u201311) with a peak mean level of 2.79\/10 at Day 10. Aside from lower grade (\u22642), headaches, constipation, and diarrhea were the most widely reported adverse effects. Conclusion: The combination of NEPA and dexamethasone is safe and effective for the prevention of CINV in patients receiving BEAM conditioning therapy prior to HCT. The regimen demonstrated greater effectiveness in the acute phase versus the delayed phase, with low levels of nausea throughout the study period and complete emesis prevention during chemotherapy.<\/jats:p>","DOI":"10.1177\/10781552231173863","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T02:46:01Z","timestamp":1683513961000},"page":"304-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A phase II trial of netupitant\/palonosetron for prevention of chemotherapy-induced nausea\/vomiting in patients receiving BEAM prior to hematopoietic cell transplantation"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7873-1597","authenticated-orcid":false,"given":"Joseph S","family":"Bubalo","sequence":"first","affiliation":[{"name":"Oregon Health & Science University, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Radke","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G","family":"Bensch","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, OR, USA"},{"name":"VA Portland Health Care System, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy I","family":"Chen","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Misra","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T","family":"Maziarz","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, OR, USA"},{"name":"Center for Hematologic Malignancies, OHSU Knight Cancer Institute, Beaverton, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"bibr1-10781552231173863","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01296"},{"key":"bibr2-10781552231173863","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3449-y"},{"key":"bibr3-10781552231173863","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00019"},{"key":"bibr4-10781552231173863","doi-asserted-by":"publisher","DOI":"10.1177\/1078155209105399"},{"key":"bibr5-10781552231173863","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(01)80011-2"},{"key":"bibr6-10781552231173863","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0106-8"},{"key":"bibr7-10781552231173863","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S133943"},{"key":"bibr8-10781552231173863","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-014-4017-7"},{"key":"bibr9-10781552231173863","unstructured":"National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology: Antiemesis [v1.2021]. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/antiemesis.pdf (accessed October 2021)."},{"key":"bibr10-10781552231173863","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw270"},{"key":"bibr11-10781552231173863","unstructured":"Aapro M, Gralla RJ, Herrstedt J, et al. MASCC\/ESMO antiemetic guideline 2016 with updates in 2019. MASCC website. September 5, 2019. https:\/\/www.mascc.org\/assets\/Guidelines-Tools\/mascc_antiemetic_guidelines_english_v.1.5SEPT29.2019.pdf.new (accessed 30 December 2020)."},{"key":"bibr12-10781552231173863","unstructured":"Netupitant and Palonosetron. Lexi-Drugs. Hudson, OH: Lexicomp, 2021. http:\/\/online.lexi.com\/. 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