{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:56:12Z","timestamp":1783364172954,"version":"3.54.6"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T00:00:00Z","timestamp":1683417600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04378\/2020"],"award-info":[{"award-number":["UIDP\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Pharmacy personnel that manipulate cytotoxic drugs are under continuous exposure risk. Therefore, training and strict adherence to recommended practices should always be promoted. The main objective of this study was to develop and apply a safe, effective and low-cost method for the training and assessment of the safe handling of cytotoxic drugs, using commercially available tonic water. To evaluate the potential of tonic water as a replacement marker for quinine hydrochloride, deliberate spills of 1\u2005mL of four different tonic waters (one coloured and three non-coloured) were analysed under ultraviolet light (300\u2013400\u2005nm). The pigmented sample did not produce fluorescence under ultraviolet (UV) light. The three commercially available tonic waters that exhibited fluorescence were further analysed by UV\/Vis spectrophotometry (300\u2013500\u2005nm). Afterwards, a protocol of simulated manipulation of cytotoxic drugs was developed and applied to 12 pharmacy technicians, that prepared 24 intravenous bags according to recommended routine procedures using tonic water. Participants responded to a brief questionnaire to evaluate the adequacy and applicability of the activity. Seven of the participants had spillages during manipulation, the majority of which recorded during manipulation with needles. All participants scored the tonic water manipulation simulation with 4 or 5 points for simplicity, efficiency and feasibility. The obtained results suggest that tonic water can be used to simulate the manipulation of cytotoxic drugs in training and assessment programs. By using this replacement marker for quinine hydrochloride, it is possible to perform a more cost-effective, yet equally effective, assessment.<\/jats:p>","DOI":"10.1177\/10781552231173878","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:55:45Z","timestamp":1683510945000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs"],"prefix":"10.1177","volume":"30","author":[{"given":"Nuro","family":"Ali","sequence":"first","affiliation":[{"name":"Associate Laboratory i4HB - Institute for Health and Bioeconomy, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal"},{"name":"UCIBIO\/REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Carmo","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB - Institute for Health and Bioeconomy, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal"},{"name":"UCIBIO\/REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Robalo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o Farmac\u00eautico do Centro Hospitalar de Vila Nova de Gaia\/Espinho, E.P.E., Vila Nova de Gaia, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Servi\u00e7o Farmac\u00eautico do Centro Hospitalar de Vila Nova de Gaia\/Espinho, E.P.E., Vila Nova de Gaia, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o Farmac\u00eautico do Centro Hospitalar de Vila Nova de Gaia\/Espinho, E.P.E., Vila Nova de Gaia, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-1459","authenticated-orcid":false,"given":"Fernando","family":"Moreira","sequence":"additional","affiliation":[{"name":"Escola Superior de Sa\u00fade, Instituto Polit\u00e9cnico do Porto, Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Ambiente, Escola Superior de Sa\u00fade, Instituto Polit\u00e9cnico do Porto, Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"bibr1-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1177\/10781552211040176"},{"key":"bibr2-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(99)00002-9"},{"key":"bibr3-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1007\/s43188-019-00003-7"},{"key":"bibr4-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.05.001"},{"key":"bibr5-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(98)00180-6"},{"key":"bibr6-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1177\/10781552211003638"},{"key":"bibr7-10781552231173878","volume":"28","author":"International Society of Oncology Pharmacy Practitioners I","year":"2022","journal-title":"J Oncol Pharm Pract"},{"key":"bibr8-10781552231173878","doi-asserted-by":"publisher","DOI":"10.17265\/2159-5313\/2016.09.003"},{"key":"bibr9-10781552231173878","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp180564"},{"key":"bibr10-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1177\/1078155212452764"},{"key":"bibr11-10781552231173878","first-page":"24","volume":"8","author":"Baussant G","year":"2014","journal-title":"Eur J Oncol Pharm"},{"key":"bibr12-10781552231173878","first-page":"32","volume":"1","author":"Jenn NC","year":"2006","journal-title":"Malays Fam Physician"},{"key":"bibr13-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1177\/1078155221995539"},{"key":"bibr14-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1177\/001857870303800213"},{"key":"bibr15-10781552231173878","doi-asserted-by":"publisher","DOI":"10.1021\/es0519381"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552231173878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552231173878","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552231173878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:28:24Z","timestamp":1777688904000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552231173878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,7]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1177\/10781552231173878"],"URL":"https:\/\/doi.org\/10.1177\/10781552231173878","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,7]]}}}