{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:05:08Z","timestamp":1792695908582,"version":"4.5.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Imatinib is a first-line selective tyrosine kinase inhibitor used for the treatment of chronic myeloid leukemia. Although imatinib-induced hepatotoxicity may aggravate the patient's clinical condition and alter the treatment plan, the mechanism of imatinib-induced hepatotoxicity has rarely been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report a 51-year-old man, suffering from acute toxic hepatitis after 5 months of imatinib treatment for chronic myeloid leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>The outcome was favorable after discontinuation of treatment with normalization of biological liver function after 12 weeks. The treatment was switched to nilotinib without any incidents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Regular liver function test monitoring is recommended during imatinib treatment. In fact of acute hepatic toxicity, treatment with imatinib should be stopped in the case of cytolysis more than five times the upper limit of normal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231188307","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T02:22:59Z","timestamp":1689733379000},"page":"2027-2030","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Imatinib mesylate-induced acute hepatotoxicity"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0400-7333","authenticated-orcid":false,"given":"Imen","family":"Frikha","sequence":"first","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4599-6556","authenticated-orcid":false,"given":"Yousra","family":"Fakhfakh","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Sahnoun","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lassaad","family":"Chtourou","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology, Hedi Chaker Hospital, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Medhaffar","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Elloumi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hedi Chaker Hospital, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"bibr1-10781552231188307","doi-asserted-by":"publisher","DOI":"10.1007\/s12157-011-0273-3"},{"key":"bibr2-10781552231188307","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2016.02.009"},{"key":"bibr3-10781552231188307","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2019.09.004"},{"key":"bibr4-10781552231188307","first-page":"935","volume":"8","author":"Cohen MH","year":"2002","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"bibr5-10781552231188307","unstructured":"Laboratoire novartis. monographie de produit incluant les renseignements pour les patients sur les m\u00e9dicaments gleevec md \u2013 pdf. 2001"},{"key":"bibr6-10781552231188307","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161120-00007"},{"key":"bibr7-10781552231188307","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402702"},{"key":"bibr8-10781552231188307","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011573"},{"key":"bibr9-10781552231188307","volume":"49","author":"Thia TJK","year":"2008","journal-title":"Singapore Med J"},{"key":"bibr10-10781552231188307","volume":"91","author":"Ferrero D","year":"2006","journal-title":"Haematologica"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552231188307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552231188307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552231188307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:28:45Z","timestamp":1777688925000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552231188307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/10781552231188307"],"URL":"https:\/\/doi.org\/10.1177\/10781552231188307","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]}}}