{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:53:15Z","timestamp":1781023995663,"version":"3.54.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Drug interactions constitute a significant issue in cancer treatment. Therefore, it is important to assess and analyze all cancer patients\u2019 therapies prior to the initiation of chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted at the Near East University Hospital Oncology Department located in North Cyprus between June 2019 and December 2021. The aim of the study was to determine the nature, type, and frequency of potential drug\u2013drug interactions in breast cancer patients receiving a doxorubicin and cyclophosphamide regimen using Drugs.com, Lexicomp, and Micromedex databases while comparing the three electronic databases, according to the frequency, mechanism, and severity of drug\u2013drug interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 40 patients (44.4%) out of 90 patients diagnosed with breast cancer, as 50 patients (55.6%) who did not match the criteria were excluded. According to the Lexicomp database, 12 patients (30%) with breast cancer had 14 potential drug\u2013drug interactions, according to the Drugs.com database, 15 patients (37.5%) with breast cancer had 22 potential drug\u2013drug interactions, and according to the Micromedex database, 13 patients (32.5%) with breast cancer had 15 potential drug\u2013drug interactions. Pearson correlation indicated a weak association (Lexicomp: r\u2009=\u20090.475, p\u2009=\u20090.002 and Micromedex: r\u2009=\u20090.491, p\u2009=\u20090.001) and a moderate association (Drugs.com: r\u2009=\u20090.500, p\u2009=\u20090.001) between potential drug\u2013drug interactions and five or more medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed that the Drugs.com database detected more potential drug interactions between chemotherapy and nonchemotherapy than the Lexicomp and Micromedex databases. Comprehensive drug review, use of electronic health record systems, and collaboration between healthcare providers such as pharmacists and physicians may be necessary strategies to minimize potential drug\u2013drug interactions and optimize cancer treatment in patients with breast cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231189700","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T02:42:22Z","timestamp":1690252942000},"page":"830-843","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Determination of drug\u2013drug interaction in breast cancer patients receiving doxorubicin and cyclophosphamide regimen"],"prefix":"10.1177","volume":"30","author":[{"given":"Mona","family":"Mahfouz","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Near East University, North Cyprus, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid Nabeel","family":"Alkhalid","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Near East University, North Cyprus, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5785-2333","authenticated-orcid":false,"given":"Nevzat","family":"Birand","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Near East University, North Cyprus, Turkey"},{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Cyprus International University, North Cyprus, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"bibr1-10781552231189700","unstructured":"American Cancer Society. Cancer Facts for Women, https:\/\/www.cancer.org\/search.html?q=breast+cancer+american (accessed 15 April 2022)."},{"key":"bibr2-10781552231189700","unstructured":"World health organization. Cancer, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer (accessed 15 April 2022)."},{"key":"bibr3-10781552231189700","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1510-145"},{"key":"bibr4-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0459-6"},{"key":"bibr5-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq761"},{"key":"bibr6-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.01.006"},{"key":"bibr7-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00080-7"},{"key":"bibr8-10781552231189700","doi-asserted-by":"publisher","DOI":"10.2165\/11534400-000000000-00000"},{"key":"bibr9-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2001.00892.x"},{"key":"bibr10-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1177\/00185787211073464"},{"key":"bibr11-10781552231189700","unstructured":"Boster B, Patel NK and Michaud L. Breast cancer. In: DiPiro JT, Yee GC, Posey L, et al (eds)\n                      Pharmacotherapy: A pathophysiologic approach\n                      , 11e. New York, NY: McGraw Hill, 2020, pp. 6376\u20136471. https:\/\/accesspharmacy.mhmedical.com\/content.aspx?bookid=2577&ionid=23976218 (accessed 01 April 2022)."},{"key":"bibr12-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-021-04311-4"},{"key":"bibr13-10781552231189700","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.4103\/njcp.njcp_266_20","volume":"24","author":"Laban AA","journal-title":"Niger J Clin Pract"},{"key":"bibr14-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk130"},{"key":"bibr15-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-015-0195-z"},{"key":"bibr16-10781552231189700","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-1079"},{"key":"bibr17-10781552231189700","unstructured":"Raosoft, Inc. Raosoft Inc. 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