{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:56:13Z","timestamp":1790880973259,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cachexia is associated with increased morbidity and mortality rates in patients with cancer. This meta-analysis aims to explore the effect of anamorelin on cancer cachexia markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE\/PubMed, SCOPUS, and WOS from their inception until 5 June 2022. A systematic search was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. We included trials investigating the effect of anamorelin on body weight, lean body mass, fat mass, insulin-like growth factor 1 (IGF-1), handgrip, quality of life insulin-like growth factor-binding protein 3 (IGFBP-3), and in patients with cancer. A random-effects model was run to pooled results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five articles providing 1331 participants were analyzed in this study. Pooled analysis revealed a significant increase in body weight (weighted mean difference (WMD): 1.56\u2005kg, 95% confidence interval (CI): 1.20, 1.92; I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), lean body mass (WMD: 1.36\u2005kg, 95% CI: 0.85, 1.86; I\n                      <jats:sup>2<\/jats:sup>\n                      = 53.1%), fat mass (WMD: 1.02\u2005kg, 95% CI: 0.51, 1.53; I\n                      <jats:sup>2<\/jats:sup>\n                      = 60.7%), IGF-1 (WMD: 51.16\u2005ng\/mL, 95% CI: 41.42, 60.90, I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), and IGFBP-3 (WMD: 0.43 \u03bcg\/mL, 95% CI: 0.17, 0.68, I\n                      <jats:sup>2<\/jats:sup>\n                      = 98.6%). Results showed no significant increase in appetite when analysis run on all studies without considering different doses 0.29 (95% CI: \u22120.30, 0.89, I\n                      <jats:sup>2<\/jats:sup>\n                      = 73.8%), however, there was a significant increase in appetite without heterogeneity and inconsistency 0.59 (95% CI: 0.32, 0.86; I\n                      <jats:sup>2<\/jats:sup>\n                      = 0%) in the 100\u2005mg\/day group compared to anamorelin non-user.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with cancer who receive anamorelin as a treatment for cachexia showed a significant increase in body weight, lean body mass, fat mass, IGF-1, and IGFBP-3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231189864","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T03:50:17Z","timestamp":1690861817000},"page":"1725-1735","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of anamorelin (ONO-7643) on cachexia in cancer patients: Systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1177","volume":"29","author":[{"given":"Shahla","family":"Rezaei","sequence":"first","affiliation":[{"name":"Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Costa","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Rio de Janeiro, RJ, 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