{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:45Z","timestamp":1777934625559,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>High-risk febrile neutropenia (FN) is one of the main causes of morbidity and mortality in onco-hematology. The initiation of empirical antibiotic therapy is an emergency that can change the prognosis of some patients. Given the emergence of increasingly resistant Gram-positive bacteremia, glycopeptides, as an empirical treatment, have an important place in the management of high-risk FN. The aim of this study is to evaluate the appropriateness of glycopeptide prescription in high-risk FN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted in the Hematology Department of Fattouma Bourguiba University Hospital of Monastir, Tunisia. Patients with high-risk FN were enrolled during the period between January 1 and December 31, 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 29 patients included in this study, 88 FN episodes were noted of which 39 episodes treated with glycopeptides were evaluated. Twenty-four febrile episodes were empirically treated with glycopeptides (27.3%) of which 17 prescriptions (70.8%) were appropriate according to the European Conference on Infection in Leukemia and the Infectious Diseases Society of America recommendations. A therapeutic escalation using glycopeptides was noted in 17% of cases and appropriately opted in 6 FN episodes (40%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prescriptions of glycopeptides were appropriate according to the international recommendations in 71% of the empirical prescriptions and in 40% of the therapeutic escalation using glycopeptides. In high-risk FN episodes, glycopeptides prescriptions should be rationalized and limited to the indications detailed in the international guidelines to control the emergence of multidrug-resistant bacteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231191718","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:27:42Z","timestamp":1690763262000},"page":"964-970","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of glycopeptide prescription in high-risk febrile neutropenia: A monocentric study of North Africa"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1760-7533","authenticated-orcid":false,"given":"Wiem","family":"Boufrikha","sequence":"first","affiliation":[{"name":"Hematology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-0464","authenticated-orcid":false,"given":"Rim","family":"Rakez","sequence":"additional","affiliation":[{"name":"Hematology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baraa","family":"Laabidi","sequence":"additional","affiliation":[{"name":"Hematology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Adnene","family":"Laatiri","sequence":"additional","affiliation":[{"name":"Hematology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"bibr1-10781552231191718","doi-asserted-by":"publisher","DOI":"10.2174\/1573396314666180508121625"},{"key":"bibr2-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02561-14"},{"key":"bibr3-10781552231191718","first-page":"55","volume":"32","author":"Escrihuela-Vidal F","year":"2019","journal-title":"Rev Esp Quimioter"},{"key":"bibr4-10781552231191718","first-page":"2741","volume":"18","author":"Osmani AH","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"key":"bibr5-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq147"},{"key":"bibr6-10781552231191718","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.091025"},{"key":"bibr7-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(85)90080-X"},{"key":"bibr8-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.E0633"},{"key":"bibr9-10781552231191718","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.03.125"},{"key":"bibr10-10781552231191718","volume":"9","author":"Alp S","year":"2017","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"bibr11-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2006.00123.x"},{"key":"bibr12-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1177\/1078155215597558"},{"key":"bibr13-10781552231191718","doi-asserted-by":"publisher","DOI":"10.4103\/jrpp.JRPP_18_16"},{"key":"bibr14-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30211-9"},{"key":"bibr15-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2001.0798"},{"key":"bibr16-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1016\/j.idh.2019.08.006"},{"key":"bibr17-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-137"},{"key":"bibr18-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59814-6"},{"key":"bibr19-10781552231191718","first-page":"539","volume":"23","author":"von Lilienfeld-Toal M","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"bibr20-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0830-6"},{"key":"bibr21-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0987-6"},{"key":"bibr22-10781552231191718","doi-asserted-by":"publisher","DOI":"10.1086\/505393"},{"key":"bibr23-10781552231191718","unstructured":"Masmoudi S, Khanfir A, Maalej-Mezghan S, et al. les neutrop\u00e9nies f\u00e9briles chimio-induites: a propos de 186 \u00e9pisodes aspects \u00e9pid\u00e9miologiques, diagnostiques et th\u00e9rapeutiques La tunisie Medicale. 2015; 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