{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:58:29Z","timestamp":1784170709937,"version":"3.55.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Asparaginase derivatives are essential components of the treatment of acute lymphoblastic leukemia in adolescent and young adult patients. However, their associated toxicities limit wider use in older populations. This study seeks to determine if the practice of capping the pegaspargase dose at 3750\u2005units reduces the risk of related adverse events in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adverse event data were retrospectively collected 28 days following each administration of pegaspargase in a single center. Doses were categorized as either capped (\u22643750\u2005units) ( n\u2009=\u200957, 47.5%) or non-capped (&gt;3750\u2005units) ( n\u2009=\u200963, 52.5%). The primary endpoint of this study was the composite incidence of serious pegaspargase-related adverse events, defined as grade 3 or higher.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 120 doses administered, 47 (39.2%) were administered to patients \u2009&gt;\u200939 years. For the primary endpoint, 26 doses (45.6%) in the dose capped group versus 22 doses (34.9%) in the non-dose capped group were associated with serious pegaspargase-related adverse events ( p\u2009=\u20090.23). Isolated laboratory abnormalities accounted for all hepatotoxicity and pancreatic toxicity events, while venous thromboembolism and bleeding occurred after 8.3% and 13.3% of doses, respectively. Multivariate analysis of the primary outcome to adjust for differences in baseline characteristics found no difference between groups (OR 2.56 (0.84, 7.77, p\u2009=\u20090.098)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of serious clinical toxicities was low in this study, particularly pegaspargase-related venous thromboembolism. This suggests that the practice of capping pegaspargase doses at 3750\u2005units, coupled with vigilant monitoring and prophylaxis for pegaspargase-related adverse events, can allow for the inclusion of this drug in the treatment of older individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231202217","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T06:53:15Z","timestamp":1695192795000},"page":"1130-1137","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of pegaspargase dose capping on incidence of pegaspargase-related adverse events in adults"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2325-6474","authenticated-orcid":false,"given":"Emily","family":"Tiao","sequence":"first","affiliation":[{"name":"University of Maryland School of Pharmacy, Baltimore, MD, USA"},{"name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciera L","family":"Bernhardi","sequence":"additional","affiliation":[{"name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Trovato","sequence":"additional","affiliation":[{"name":"University of Maryland School of Pharmacy, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Lawson","sequence":"additional","affiliation":[{"name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunuk","family":"Seung","sequence":"additional","affiliation":[{"name":"University of Maryland School of Pharmacy, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Emadi","sequence":"additional","affiliation":[{"name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA"},{"name":"University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9018-3722","authenticated-orcid":false,"given":"Alison P","family":"Duffy","sequence":"additional","affiliation":[{"name":"University of Maryland School of Pharmacy, Baltimore, MD, USA"},{"name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"bibr1-10781552231202217","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.184769"},{"key":"bibr2-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-881961"},{"key":"bibr3-10781552231202217","doi-asserted-by":"publisher","DOI":"10.2217\/ijh-2017-0023"},{"key":"bibr4-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-045351"},{"key":"bibr5-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01120-1"},{"key":"bibr6-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.2708"},{"key":"bibr7-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1177\/1078155219838316"},{"key":"bibr8-10781552231202217","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020536"},{"key":"bibr9-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.05.010"},{"key":"bibr10-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-431460"},{"key":"bibr11-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26555"},{"key":"bibr12-10781552231202217","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.219"},{"key":"bibr13-10781552231202217","volume-title":"Pegaspargase 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