{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:13:12Z","timestamp":1792699992047,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In recent years, a new type of immediate hypersensitivity reaction known as cytokine release began to emerge, and within this phenotype of reactions, interleukin-6 is the most frequently associated with the presence during drug administration. Chemotherapeutic agents (QT) and monoclonal antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Determine interleukin-6 levels in hypersensitivity reactions to QT and monoclonal antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational and prospective study that was carried out from March 1, 2021 to March 1, 2022 in a university hospital in northeastern Mexico. Symptoms, severity, interleukin-6 levels, and skin tests of hypersensitivity reaction were evaluated at QT and monoclonal antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 41 patients with oncological disease were included, the most frequent being ovarian cancer. Symptoms as initial hypersensitivity reaction were neuromuscular in taxanes and cutaneous in Platinums. 41.5% presented elevation of interleukin-6, and it was found more frequently in presence of metastases. Positive skin tests were found more frequently in the carboplatin and doxorubicin groups. The most frequently presented phenotype was type I in paclitaxel, carboplatin, and doxorubicin, and mixed-reaction (type I and cytokine release) in oxaliplatin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With the increasing prevalence of hypersensitivity reactions to biologic and antineoplastic therapies, interleukin-6 should be recognized as a biomarker in immediate hypersensitivity reactions to QT and monoclonal antibodies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231204367","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:54:00Z","timestamp":1696992840000},"page":"1294-1301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin-6 as a biomarker of hypersensitivity reactions in chemotherapeutics and monoclonal antibodies"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-6934","authenticated-orcid":false,"given":"Rosalaura V","family":"Villarreal-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Oncology Service, Centro Universitario Contra el C\u00e1ncer (CUCC), Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Monterrey, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-0042","authenticated-orcid":false,"given":"Sandra","family":"Gonz\u00e1lez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Regional Center of Allergy and Clinical Immunology, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Monterrey, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-8525","authenticated-orcid":false,"given":"Oscar","family":"Vidal-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Oncology Service, Centro Universitario Contra el C\u00e1ncer (CUCC), Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Monterrey, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"de la Cruz-de la Cruz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad de Monterrey, Christus Muguerza Alta Especialidad, Monterrey, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana C","family":"P\u00e9rez-Ibave","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Oncology Service, Centro Universitario Contra el C\u00e1ncer (CUCC), Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Monterrey, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L","family":"Garza-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Oncology Service, Centro Universitario Contra el C\u00e1ncer (CUCC), Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Monterrey, Nuevo Le\u00f3n, 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